Reserpine does not prevent 3,4-methylenedioxymethamphetamine-induced neurotoxicity in the rat
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Breathing new life into neurotoxic-based monkey models of Parkinson's disease to study the complex biological interplay between serotonin and dopamine
2021, Progress in Brain ResearchCitation Excerpt :Previous data obtained in rats have suggested that the effects of MDMA, in particular the decrease in 5-HT concentration and the decrease in activity of tryptophan hydroxylase 2 (TPH2, the 5-HT synthetic enzyme), are based on an intact DA system (Brodkin et al., 1993; Schmidt et al., 1990; Stone et al., 1988). On the contrary, another study showed a persistent reduction of SERT fibers despite prior DA lesion (Hekmatpanah et al., 1989). If dopamine predisposes neurochemical and/or neurotoxic effects of MDMA, then the striatum should show a decrease in the binding of DASB in addicts to ecstasy, which is not the case (Kish et al., 2010).
Effects of mCPP on the extracellular concentrations of serotonin and dopamine in rat brain
1999, NeuropsychopharmacologyThe spin trap reagent α-phenyl-N-tert-butylnitrone prevents 'ecstasy'-induced neurodegeneration of 5-hydroxytryptamine neurones
1995, European Journal of PharmacologyVesicular monoamine transporter 2 and the acute and long-term response to 3,4-(±)- methylenedioxymethamphetamine
2015, Toxicological SciencesAcute and long-term of MDMA on cerebral dopamine biochemistry and function
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