Histamine excites pedunculopontine neurones in guinea pig brainstem slices
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Cited by (37)
Reciprocal interaction between monoaminergic systems and the pedunculopontine nucleus: Implication in the mechanism of L-DOPA
2019, Neurobiology of DiseaseCitation Excerpt :The release of GABA from GABAergic inputs originating from the internal segment of the globus pallidus (GPi)/SNr and other sources causes postsynaptic inhibition in both cholinergic and noncholinergic neurons (Kang & Kitai, 1990). In contrast, histamine and hypocretin/orexin activate respectively H1 (Khateb et al., 1990) and orexin 1 receptors to increase excitability of these cells (Kim et al., 2009). Like the anatomy, the influence of monoamines on PPN/LDT activity is unclear and would deserve additional studies.
Histaminergic Modulation of Recognition Memory
2018, Handbook of Behavioral NeuroscienceCitation Excerpt :All of these evidences confirmed the role of histamine in the sleep–wake cycle. Histamine maintains wakefulness through direct projections of the TMN to the thalamus and the cortex and indirectly through activation of other ascending arousal systems, mainly cholinergic (Khateb et al., 1990, 1995; Xu et al., 2004) and aminergic nuclei (Brown et al., 2001; Korotkova et al., 2002, 2005). The regulation of the transition between wakefulness and sleep involves antagonist influences of sleep-promoting ventrolateral preoptic nucleus (VLPO) neurons, which provide inhibitory GABA- and galanin-mediated inputs to TMN and brainstem cholinergic and monoaminergic groups, and excitatory effects of Hcrt/Orx neurons on the TMN and other wake-active neuronal groups (Benarroch, 2010).
Neuroanatomical Basis of Consciousness
2015, The Neurology of Consciousness: Cognitive Neuroscience and NeuropathologyConsciousness and Subcortical Arousal Systems
2014, Neuronal Networks in Brain Function, CNS Disorders, and TherapeuticsDischarge properties of presumed cholinergic and noncholinergic laterodorsal tegmental neurons related to cortical activation in non-anesthetized mice
2012, NeuroscienceCitation Excerpt :In cholinergic MS neurons, the shoulder seen in the extracellular action potential has been shown to reflect the deflection seen during the descending phase of the intracellular action potential, the position of the shoulder varying from cell to cell (Matthews and Lee, 1991). This deflection during the descending phase of the intracellular action potential has also been demonstrated in the cholinergic nucleus basalis in guinea-pig brain slices (Khateb et al., 1992) or LDT/PPT neurons in rat or guinea-pig brain slices (Khateb et al., 1990; Takakusaki et al., 1997). In a recent study in urethane anesthetized rats, Boucetta and Jones (2009) did not observe a triphasic shape of the action potential in cholinergic LDT/SubLDT neurons, but it is not clear whether or not their cholinergic neurons showed a shoulder or deflection during the descending phase of their large-amplitude action potentials (>3 mV), as a large-amplitude spike can often obscure the shoulder seen during the early phase of the action potential, as shown in the present study (Fig. 6A).
Histamine in the regulation of wakefulness
2011, Sleep Medicine ReviewsCitation Excerpt :However, H3 receptor mediated electrophysiological actions have not been reported.86 The cholinergic neurons of the mesopontine tegmentum and basal forebrain are excited by histamine, mediated via the activation of H1 receptor.87,88 Activation of H3 receptor results in the depression of cholinergic neurons coupled with reduction in cortical acetylcholine release.89,90