High ethanol sensitivity of recombinant AMPA-type glutamate receptors expressed in mammalian cells
References (25)
- et al.
The non-NMDa receptors: types, protein structure and molecular biology
Trends Pharmacol. Sci.
(1990) - et al.
Acute ethanol alters the firing pattern and glutamate response of cerebellar Purkinje neurons in culture
Brain Res.
(1987) - et al.
The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits
Neuron
(1992) - et al.
Ethanol potentiates and blocks NMDA-activated single-channel currents in rat hippocampal pyramidal cells
FEBS Lett.
(1989) - et al.
Kinetic analysis of interactions between kainate and AMPA: evidence for activation of a single receptor in mouse hippocampal neurons
Neuron
(1991) - et al.
Barbiturates, alcohols and the CNS excitatory neurotransmission: specific effects on the kainate and quisqualate receptors
Brain Res.
(1984) - et al.
Interactions between phencyclidine and central nervous system depressants evaluated in mice and rats
Pharmacol. Biochem. Behav.
(1987) - et al.
NMDA agonists and antagonists alter the hypnotic response to ethanol in LS and SS mice
Alcohol
(1990) - et al.
Mechanism of inhibition of increases in free intracellular calcium by ethanol
J. Neurochem.
(1991) - et al.
Glutamate receptor subunits expressed in Xenopus oocytes demonstrate differing sensitivities to ethanol
Soc. Neurosci. Abstr.
(1992)
Ethanol attenuates the response of locus coeruleus neurons to excitatory amino acid agonists in vivo
Naunyn-Schmiedeberg's Arch. Pharmacol.
Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA
Nature
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Alcohol: Neurobiology of Addiction
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2020, Neurobiology of Learning and MemoryCitation Excerpt :These receptors are involved in synaptic plasticity and learning and memory (Artola & Singer, 1987). In addition to modulating GABAA and NMDA receptor function, alcohol also influences AMPA, kainate, glycine, and nicotinic acetylcholine receptor function (Lovinger, 1993; Weiner, Dunwiddie, & Valenzuela, 1999; Mihic et al., 1997; Cardoso et al., 1999). AMPA and kainate receptors are important components of glutamatergic signaling (for review, see Bettler & Mulle, 1995), and glycine is important in inhibitory neurotransmission (Werman, Davidoff, & Aprison, 1968).
Glutamate Signaling in Alcohol Abuse and Dependence
2014, Neurobiology of Alcohol DependenceGlutamate Plasticity in the Drunken Amygdala. The Making of an Anxious Synapse
2010, International Review of NeurobiologyCitation Excerpt :AMPA-mediated synaptic responses from locus ceruleus (Nieber et al., 1998) and spinal motoneurons (Ziskind-Conhaim et al., 2003) are likewise insensitive to the direct, postsynaptic effects of acute ethanol. This rather modest sensitivity of AMPA receptors to intoxicating concentrations of acute ethanol has also been noted in whole-cell currents from cultured cortical neurons (Lovinger, 1993), acutely isolated medial septum/diagonal band neurons (Frye and Fincher, 2000), and AMPA-gated whole-cell currents recorded from nucleus accumbens neurons in brain slices (Nie et al., 1994). This latter finding contrasts with earlier work in the nucleus accumbens showing robust ethanol sensitivity of AMPA-mediated excitatory postsynaptic potentials (Nie et al., 1993).
Ethanol increases desensitization of recombinant GluR-D AMPA receptor and TARP combinations
2009, AlcoholCitation Excerpt :In heterologous expression systems, all AMPA receptor subunits can form functional receptors as homomers. Ethanol inhibits the function of ionotropic glutamate receptors (Dildy-Mayfield and Harris, 1992; Lovinger, 1993; Lovinger et al., 1990). N-methyl-d-aspartate (NMDA) receptors are considered to be the most important target among the glutamate receptors in acute actions of ethanol.