Catechol-O-methyltransferase (COMT) in rat brain: immunoelectron microscopic study with an antiserum against rat recombinant COMT protein☆
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2011, Journal of Biological ChemistryCitation Excerpt :Despite this wealth of information about the biochemistry and neurobiology of COMT, surprisingly little is known about the cell biology of MB-COMT. The cellular distribution and the orientation of MB-COMT on the cellular membrane of neurons including pyramidal neurons are controversial (11, 30–32). Indeed, a recent study in mice proposed that MB-COMT is not localized to the cell membrane, suggesting that dopamine would have to be transported from outside the cell for it to be metabolized by COMT (30).
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Supported by research grants from the Medical Research Council of Academy of Finland, The Sigrid Juselius Foundation and Research and Science Foundation of Farmos.