Region-specific changes in GABAA receptor δ subunit mRNA level by tolerance to and withdrawal from pentobarbital☆
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Cited by (15)
Mechanisms of action of antiseizure drugs
2012, Handbook of Clinical NeurologyCitation Excerpt :GABA may act as a partial agonist at extrasynaptic δ-subunit-containing GABAA receptor isoforms that mediate tonic inhibition, which may render them particularly sensitive to allosteric modulation by barbiturates (Feng et al., 2004). Interestingly, chronic treatment with barbiturates causes an increase in GABAA receptor δ subunit mRNA; withdrawal results in downregulation (Lin and Wang, 1996). Thus, the relative activity of barbiturates on synaptic and extrasynaptic GABAA receptors may vary with drug exposure.
AMPA/kainate receptor-mediated up-regulation of GABA<inf>A</inf> receptor δ subunit mRNA expression in cultured rat cerebellar granule cells is dependent on NMDA receptor activation
2006, Brain ResearchCitation Excerpt :However, in the study of Kim et al., δ mRNA was slightly (15%) up-regulated by MK-801 treatment in cerebellar granule cell layer. Furthermore, up-regulation of δ mRNA expression in the cerebellum by tolerance to pentobarbital, and down-regulation by withdrawal from it have been reported (Lin and Wang, 1996), suggesting that increase in neuronal activity does not necessarily increase δ mRNA expression. In conclusion, prolonged activation of various classes of GluRs causing depolarization up-regulates GABAAR δ subunit mRNA expression in rat CGCs in culture.
Drug interactions at GABA<inf>A</inf> receptors
2002, Progress in NeurobiologyGenetic determinants of severity of acute withdrawal from diazepam mice: Commonality with ethanol and pentobarbital
1999, Pharmacology Biochemistry and BehaviorAn update on GABA(A) receptors
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This work was supported by grant NSC-84-2331-B-182-037 from the National Science Council of Republic of China and by grant CMRP444 from Chang Gung Memorial Hospital.