Effects of peripheral nerve ligation on expression of μ-opioid receptor in sensory ganglion neurons: an immunohistochemical study in dorsal root and nodose ganglion neurons of the rat☆
References (15)
- et al.
The reaction of primary sensory neurons to peripheral nerve injury with particular emphasis on transganglionic changes
Brain Res. Rev.
(1985) - et al.
Cell loss in lumbar dorsal root ganglia and transganglionic degeneration after sciatic nerve resection in the rat
Brain Res.
(1986) - et al.
Co-localization of μ-opioid receptor-like and substance P-like immunoreactivities in axon terminals within the superficial layers of the medullary and spinal dorsal horns of the rat
Neurosci. Lett.
(1995) - et al.
The peripheral antinociceptive effect of morphine in a rat model of facial pain
Neuroscience
(1996) - et al.
Messenger plasticity in primary sensory neurons following axotomy and its functional implications
Trends Neurosci.
(1994) - et al.
μ Opioid receptor: expression and vagotomy-induced depletion of the mRNA in medullary preganglionic neurons
Mol. Brain Res.
(1994) - et al.
Immunocytochemical localization of μ-opioid receptor in the rat caudate-putamen
Neurosci. Lett.
(1995)
Cited by (40)
Immune cell-mediated opioid analgesia
2020, Immunology LettersCitation Excerpt :Therefore, in the following sections, we focus on mu-, delta-, and kappa-receptors. All three receptors are synthetized in dorsal root ganglia (DRG) small-, medium- and, to a lesser degree, large-diameter neurons [14–18], are transported to [19–22] and accumulate at their peripheral terminals [23–26]. Opioid receptors are also expressed in neurons of trigeminal and nodose ganglia, and submucosal and myenteric plexuses of the enteric nervous system in the gastrointestinal tract [14,21,27].
Pharmacologically evoked apnoeas. Receptors and nervous pathways involved
2019, Life SciencesCitation Excerpt :They are present on primary afferent terminals, in and around the nucleus of the solitary tract (NTS), the first central synapse integrating inputs from airways and baro- and chemoreceptive structures [26,48,51–54]. It is well documented that vagal afferents, which terminate in the medial NTS, are also endowed with μ-opioid receptors [55–58]. Apnoea is assumed to arise from the stimulation of vagal sensory receptors in the lungs.
Cardiovascular and respiratory activity of PK20, opioid and neurotensin hybrid peptide in anesthetized and awake rats
2017, European Journal of PharmacologyOpioid receptors and opioid peptide-producing leukocytes in inflammatory pain - Basic and therapeutic aspects
2010, Brain, Behavior, and ImmunityCitation Excerpt :In the late 1980s, evidence began to accumulate that antinociceptive effects can be mediated by opioid receptors located on peripheral sensory neurons (Bartho et al., 1990; Stein, 1995; Stein et al., 1990b). Opioid receptors are expressed in small-, medium- and large-diameter dorsal root ganglia (DRG) neurons (Buzas and Cox, 1997; Chen et al., 1997; Coggeshall et al., 1997; Gendron et al., 2006; Mansour et al., 1994; Rau et al., 2005; Silbert et al., 2003; Wang and Wessendorf, 2001; Zhang et al., 1998a,c), they are co-expressed with prototypical sensory neuropeptides such as substance P and CGRP (Khasabova et al., 2004; Li et al., 1998; Minami et al., 1995; Mousa et al., 2007a,b; Stander et al., 2002; Zhang et al., 1998b,c), they are transported to the peripheral nerve terminals (Hassan et al., 1993; Li et al., 1996; Mousa et al., 2001), and they are coupled to Gi/o-proteins that inhibit adenylyl cyclases and modulate ion channels (Stein et al., 2009; Zöllner et al., 2003). The inhibition of Ca2+ channels appears to be a major mechanism for the suppression of sensory neuron functions (Akins and McCleskey, 1993).
Cannabinoid-opioid interactions during neuropathic pain and analgesia
2010, Current Opinion in Pharmacology
- ☆
This work was supported in part by Grants-in-Aid from the Ministry of Education, Science, Culture and Sports of Japan.
- 1
On leave from the Department of Anatomy, The Fourth Military Medical University, Xi'an, People's Republic of China.
- ∗
The authors are grateful for the support of Dr. Kajitaro Morita at the Morita Clinic of Internal Medicine and Pediatrics, Kadoma, Osaka, Japan and for the photographic help of Mr. Akira Uesugi.