Adenylate cyclase responses to sucrose stimulation in membranes of pig circumvallate taste papillae

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Abstract

  • 1.

    1. Typical adenylate cyclase (AC) responses to guanine nucleotides were found in membranes of pig circumvallate (CV) taste papillae.

  • 2.

    2. Sucrose stimulated AC activity in the CV membranes and this stimulation was GTP dependent and tissue specific.

  • 3.

    3. The stimulatory effect of sucrose in the CV membranes was dependent on the concentration of membranes used in the AC assay.

  • 4.

    4. This study provides the first biochemical data on cellular transduction of taste in the pig, compares positively to preliminary results in cattle and supports recent suggetions for a role of cAMP in sweet taste transduction.

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