Regional changes of monoamines in cerebral cortex and subcortical structures of aging rhesus monkeys

doi:10.1016/0306-4522(81)90053-1

Neuroscience

Volume 6, Issue 2, February 1981, Pages 177-187

https://doi.org/10.1016/0306-4522(81)90053-1 Get rights and content

Abstract

The concentration and rates of synthesis of monoaminergic neurotransmitters were determined in selected cortical and subcortical brain regions of rhesus monkeys ranging in age from 2 to over 18 y of age. Major changes that occur with advancing age include:

(1)
a decrease in endogenous concentrations of dopamine in restricted regions of the cerebral cortex; the reduction is most drastic in the prefrontal association cortex where the loss is over 50%;
(2)
cortical levels of norepinephrine and serotonin remain essentially unaltered in prefrontal association cortex and exhibit only slight or modest reductions in other cortical areas over the same time scale;
(3)
catecholamine biosynthesis is reduced by at least 60% in all sensory and association cortical areas between 2 and 18 y of age but is surprisingly steady in the premotor and motor cortex over the same period of time;
(4)
serotonergic activity does not change with age in any cortical or subcortical structure examined;
(5)
age-related losses in subcortical structures occur only in dopamine concentrations and/or catecholamine biosynthesis: dopamine levels fall in the caudate nucleus and hypothalamus and catecholamine synthesis declines to varying degrees in all subcortical structures studied.

These findings collectively emphasize the distinctive regional patterns and selective biochemical changes that take place in various neurotransmitter systems of the primate cerebral cortex during the process of aging.

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Regional changes of monoamines in cerebral cortex and subcortical structures of aging rhesus monkeys

Abstract

Brain Res.

Brain Res.

Brain Res.

Brain Res.

Brain Res.

Brain Res.

Expl Neurol.

Brain and Language

Brain Res.

Brain Res.

Prog. Brain Res.

Expl Neurol.

Post-mortem distribution of dopamine and homovanillic acid in human brain, variations related to age, and a review of the literature

J. Neural. Trans.

Behavior and mentation changes during therapy

The determination of dopamine by a modification of the dihydroxyindole fluorimetric assay

Br. J. Pharmac.

Conjoint native and orthphtaldiadehyde-condensate assays for the fluorimetric determination of 5-hydroxyindoles in brain

Naunyn-Schmiedebergs Arch. exp. Path. Pharmak.

Individual elution of noradrenaline (together with adrenaline), dopamine, 5-hydroxytryptamine and histamine from a single, strong cation exchange column, by means of mineral acid-organic solvent mixtures

J. Pharm. Pharmac.

Vasodilators, stimulants, and anabolic agents in the treatment of geropsychiatric patients

Aging in the rhesus monkey: debilitating effects of short-term memory

J. Geront.

Convergent thalamic and mesencephalic projections to the antero-medial cortex in the rat

J. comp. Neurol.

Quantitative assessment of changes in neuron and glial cell packing density and lipofuscin accumulation with age in the cerebral cortex of a nonhuman primate (Macaca mulatta)

Changes in biogenic amine synthesis and turnover induced by hypoxia and/or foot shock stress. II. The Central Nervous System

J. Neural. Transm.

Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey

Science, N.Y.

Age-dependent changes in central dopaminergic and other monoaminergic systems

Influence of age and time interval between death and autopsy on dopamine and 3-methoxytyramine levels in human basal ganglia

J. Neural. Transm.

Sensory processes in man during maturity and senescence