Elsevier

Neuroscience

Volume 6, Issue 1, January 1981, Pages 15-37
Neuroscience

The distribution of histamine H1-receptors in the rat brain: An autoradiographic study

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Abstract

The localization of histamine H1-receptors in the rat brain was studied at the light microscopic level by quantitative autoradiography. Receptors were labeled in vitro with [3H]mepyramine. The autoradiograms revealed a widespread distribution of these receptors throughout the brain. Areas with high receptor concentrations are: the bed nucleus of the stria terminalis, polymorphic layer of the hilus of the area dentata, ventromedial nuclei of the hypothalamus, pontine nuclei and other nuclei in the pons, the nucleus tractus solitarii and the dorsal motor nucleus of the vagus nerve. Possible relationships of the distributions of histamine H1-receptors with (a) specific anatomical systems, (b) the known distribution of histaminergic terminals and (c) the central pharmacological effects of histamine and antihistaminics are discussed.

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