Co-localization of tachykinins and calcitonin gene-related peptide in capsaicin-sensitive afferents in relation to motility effects on the human ureter in vitro
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Cited by (71)
TRPM3 channel activation inhibits contraction of the isolated human ureter via CGRP released from sensory nerves
2021, Life SciencesCitation Excerpt :Numerous studies suggest a fundamental role of primary sensory afferents as a neurogenic mechanism of ureteral peristalsis [3,4]. Stimulation of sensory nerves by electrical stimuli or capsaicin can modulate spontaneous ureteral contraction via release of neuropeptides including calcitonin gene-related peptide (CGRP), substance P (SP), and neurokinin A (NKA) [4,5]. Both SP and NKA can initiate rhythmic and long-lasting phasic contraction of isolated rat and guinea pig ureters [6].
Autonomic and sensory nerve modulation of peristalsis in the upper urinary tract
2016, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :The number and the relative proportion of the neuropeptides present within these PSNs vary between species. Immunoreactivity for tachykinins and CGRP is present in equal quantities in nerve terminals of the guinea-pig (Hua et al., 1987; Su et al., 1986) and human ureter (Edyvane et al., 1994; Hua et al., 1987) but present in rat ureter in a ratio of 1:3, respectively (Su et al., 1986). Moreover, the rat renal pelvis has been suggested to contain at least four distinct populations of PSNs, based on their relative neuropeptide content (Ferguson and Bell, 1988).
Tachykinins and Neurogenic Inflammation at Visceral Level
2009, NeuroImmune BiologyCitation Excerpt :Interstitial cystitis is further characterized by an increase in the expression of tachykinin (NK1/NK2) receptors [143,144]. Tachykinin-containing nerve fibers have been described in other human organs belonging to the genitourinary tract such as the urethra [145,146], renal pelvis, and ureter [147–149], uterus and Fallopian tubes [150,151], and erectile tissues of the penis [145,146,152]. The density is normally lower than that found in corresponding tissues of other species.
Peripheral tachykinin receptors as targets for new drugs
2001, European Journal of PharmacologySubstance P
2001, International Journal of Biochemistry and Cell Biology