Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper
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2023, Privileged Scaffolds in Drug DiscoveryAre TRPA1 and TRPV1 channel-mediated signalling cascades involved in UVB radiation-induced sunburn?
2022, Environmental Toxicology and PharmacologyCitation Excerpt :In contrast, other domains (S4–S5) of the channel have greater movement to ensure that the cation entry pore can form when activated (Liao et al., 2013) (Fig. 2). The TRPV1 channel is activated by several noxious (exogenous and endogenous) stimuli, such as high temperatures (>43 ºC) (Caterina et al., 1997; Boillat et al., 2014; Vandewauw et al., 2018), protons (pH < 5.9) (Tominaga et al., 1998), camphor (Xu et al., 2005), capsaicin (the pungent component of chili peppers) (Caterina et al., 1997), piperin, resiniferatoxin (Szallasi and Blumberg, 1989), anandamide (Zygmunt et al., 1999; Smart et al., 2000), polyamines (Ahern et al., 2006), oxytocin (Nersesyan et al., 2017), and lipoxygenase products (12-hydroxyeicosatetranoic acid, 15- hydroxy eicosatetraenoic acid) (Hwang et al., 2000). The channels are also modulated by inflammatory mediators (Chuang et al., 2001; Ma and Quirion, 2007; Zhang et al., 2008; Malek et al., 2015; Jian et al., 2016).
Use of ISSR markers to assess the genetic diversity of an endemic plant of Morocco (Euphorbia resinifera O. Berg)
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