Organization of radial glia and related cells in the developing murine CNS. An analysis based upon a new monoclonal antibody marker
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Genomic imprinting and neurodevelopment
2021, Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience of DevelopmentNeural stem cells in the adult spinal cord
2014, Experimental NeurologyCitation Excerpt :Several molecular markers associated with immature neural cells are expressed in the ependymal layer, including the intermediate filaments vimentin and nestin, and the neural stem cell associated markers CD15, Musashi1, CD133/prominin-1, Sox2, Sox3 and Sox9 (Hamilton et al., 2009; Meletis et al., 2008; Sabourin et al., 2009). Ependymal cells originate from radial glial cells, the neural stem cells in the developing central nervous system, and they express the radial glial markers RC1 and brain lipid binding protein (BLBP) (Edwards et al., 1990; Meletis et al., 2008; Sabourin et al., 2009; Spassky et al., 2005). Nestin expression is largely restricted to the dorsal and ventral poles of the ependymal layer in the uninjured spinal cord, and BLBP and CD15 expressions are restricted to the dorsal portion of the central canal region.
Early postnatal GFAP-expressing cells produce multilineage progeny in cerebrum and astrocytes in cerebellum of adult mice
2013, Brain ResearchCitation Excerpt :Interestingly, these cells were shown to derive from embryonic radial glial cells (RGCs) (Merkle et al., 2004), which are embryonic multipotent neural precursor cells that exist transiently after birth and then transform into GFAP-positive cells gradually with the development of the brain (Merkle et al., 2004; Alves et al., 2002). A number of studies have suggested that early postnatal GFAP-expressing cells are immature astrocytes (Edwards et al., 1990; Liu et al., 2002; Merkle et al., 2004; Ganat et al., 2006). Interestingly, neurospheres have been shown to arise in-vitro from young astrocytes, but not adult astrocytes (Laywell et al., 2000).
Neural stem cell survival factors
2013, Archives of Biochemistry and BiophysicsCitation Excerpt :Therefore RGC markers are also considered as NSC markers. RGC markers include vimentin [37,38], brain lipid-binding protein (BLBP) [39–41], Ephrin B1 [42], RC2 [43,44] and glutamate aspartate transporter (GLAST) [45]. CD15 serves as a RGC marker and CD15-expressing RGCs were found in developing human [46,47], wallaby [48] and mouse CNS [49,50].
Hypothalamus
2012, The Mouse Nervous SystemCerebellum
2012, The Mouse Nervous System