Tachykinins and calcitonin gene-related peptide as co-transmitters in local motor responses produced by sensory nerve activation in the guinea-pig isolated renal pelvis
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Cited by (54)
Autonomic and sensory nerve modulation of peristalsis in the upper urinary tract
2016, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :In the guinea pig, electrical field stimulation evokes a transient membrane depolarisation in the pacemaker cells in the proximal renal pelvis (Lang et al., 1995) and a transient reduction in the frequency but prolonged (for several minutes) increase in the duration of the driven TSMC action potentials in the distal renal pelvis (Lang et al., 1995) and ureter (Exintaris and Lang, 1999a). These positive inotropic and chronotropic effects of electrical or capsaicin stimulation of PSN have been attributed to the release of excitatory neuropeptides, neurokinin A and to a lesser extent substance P, being mostly blocked by the neurokinin A antagonist MEN 10376 (Maggi et al., 1992, 1994a; Santicioli and Maggi, 1998, 1998). Human CGRP (hCGRP) (Fig. 2Bv) and agents, such as IBMX, forskolin (Hashitani et al., 2009) and caffeine (Lang et al., 2006), that increase internal cAMP levels mimic PSN-mediated decreases in frequency and increases in amplitude of the TSMC Ca2 + signals and contractions, as well as the suppression of ATSMC Ca2 + transients (Hashitani et al., 2009).
Use and limitations of three TRPV-1 receptor antagonists on smooth muscles of animals and man: A vote for BCTC
2012, European Journal of PharmacologyCitation Excerpt :BCTC (1 μM) abolished the effect of 1 μM capsaicin in the guinea-pig trachea; contractions in response to 10 μM capsaicin were only weakly inhibited (Fig. 3). Capsaicin (1 μM) strongly enhanced the amplitude of the spontaneous rhythmic contractions in the renal pelvis, as described by Maggi et al. (1992). BCTC (1 μM) prevented this action (Fig. 4).
Effects of capsaicin on visceral smooth muscle: A valuable tool for sensory neurotransmitter identification
2004, European Journal of PharmacologyPrinciples of tachykininergic co-transmission in the peripheral and enteric nervous system
2000, Regulatory PeptidesCitation Excerpt :A variant of the example described above occurs in certain preparations (for example, guinea-pig bronchus and renal pelvis) in which the biological actions of TKs released from nerves is influenced by their degradation by peptidases (Fig. 2). In the guinea-pig isolated main bronchus and renal pelvis, a NANC contraction to electrical nerve stimulation can easily be demonstrated [60,61]. In the bronchus this response is preceded by a fast cholinergic component of response to electrical stimulation, whereas in the guinea-pig isolated renal pelvis a pure NANC contraction is obtained to the response to either capsaicin or electrical nerve stimulation.
Voltage-gated calcium channels in autonomic neuroeffector transmission
2000, Progress in Neurobiology