Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system
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Visible-Light-Promoted Cross Dehydrogenative/Decarboxylative Coupling Cascades of Glycine Ester Derivatives and β-Keto Acids
2022, Journal of Organic ChemistryAuto-oxidation promoted sp<sup>3</sup> C-H arylation of glycine derivatives
2018, Organic and Biomolecular ChemistryPhenylglycine analogs are inhibitors of the neutral amino acid transporters ASCT1 and ASCT2 and enhance NMDA receptor-mediated LTP in rat visual cortex slices
2017, NeuropharmacologyCitation Excerpt :These results are in agreement with reports in the literature that indicate phenylglycine analogs have either no activity at NMDA or AMPA receptors, or antagonist effects at NMDA receptors (Bigge et al., 1989; Jane et al., 1995; Contractor et al, 1998). In addition, Birse et al., 1993 indicated that NMDA antagonism was associated with D-isomers, rather than the L-forms that are the isomers active at ASCT transporters. Lack of an agonist effect on NMDA receptors is also consistent with McBain et al. (1989) who showed that L-PG is inactive as an agonist at the NMDA co-agonist site.
Supraspinal basis of analgesic and clinical effects of the metabotropic glutamate mGluR<inf>1</inf> antagonist during colonic distension in sheep
2014, Small Ruminant ResearchCitation Excerpt :mGluR existing primarily in CNS belong to subfamily C of G-protein coupled receptors divided into three distinct groups (I–III) and eight subgroups. Metabotropic receptors (except subgroup mGluR6) are widely distributed along pain neuraxis and considered for taking part in transmission of analgesic activity (Bleakman et al., 2006; Birse et al., 1993). Usage of mGluR agonists revealed that activation of these receptors in the dorsal horn facilitates pain transmission (Carlton and Neugebauer, 2002).
The role of intracellular calcium stores in synaptic plasticity and memory consolidation
2013, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Homer proteins are thought to aid the spatial and temporal signalling of IP3 between the plasma membrane mGluRs and the ER membrane-localised IP3Rs (Delmas and Brown, 2002; Xiao et al., 2000). The functional link between mGluRs and IP3Rs can be demonstrated by the use of group I mGluR antagonists (e.g. [RS]-4-carboxyphenlyglycine) which impair IP3 production (Birse et al., 1993) while mGluR agonists (e.g. (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid, ACPD) stimulate Ca2+ release from neuronal intracellular stores (Jaffe and Brown, 1994; Miller et al., 1996). In addition to mGluRs, the activation of mAChRs (M1, M3 and M5 subtypes) produces IP3 and DAG, resulting in intracellular Ca2+ release (Caulfield, 1993; Caulfield and Birdsall, 1998; Eglen, 2006; Rhee, 2001; Rhee and Bae, 1997).
Metabotropic glutamate receptors: From the workbench to the bedside
2011, Neuropharmacology