Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue
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Immune cell-mediated opioid analgesia
2020, Immunology LettersCitation Excerpt :The axonal transport of mu-receptors is increased, which results in their enhanced density at the DRG neuron peripheral terminals. This effect is dependent on electrical neuronal activity and nerve growth factor-induced activation of p38 mitogen-activated protein kinase (MAPK) in peripheral inflamed tissue [19,66–69]. The upregulation and enhanced transport of kappa-receptors were mediated by interleukin [IL]-1β [70,71].
Revisiting Oxycodone Analgesia: A Review and Hypothesis
2017, Anesthesiology ClinicsThe contribution of activated peripheral kappa opioid receptors (kORs) in the inflamed knee joint to anti-nociception
2016, Brain ResearchCitation Excerpt :Some findings have shown that peripheral ORs are localized to dorsal root ganglia cells and primary afferent axons (Coggeshall et al., 1997; Ji et al., 1995; Zhang et al., 1998). These ORs could be upregulated or transported into the peripheral terminal in inflamed tissues (Hassan et al., 1993). Based on these findings, it was hypothesized that activation of peripheral kORs by the intra-articular injection of U50488, a selective kOR agonist, into an inflamed knee joint could exert analgesic effects without side effects.
Preventive and alleviative effects of the dual enkephalinase inhibitor (Denki) PL265 in a murine model of neuropathic pain
2016, European Journal of PharmacologyOxytocin and the modulation of pain experience: Implications for chronic pain management
2015, Neuroscience and Biobehavioral ReviewsCitation Excerpt :The μ-receptor is abundantly distributed in the amygdala and thalamus; the δ-receptor in the cerebral and limbic cortices; and the κ-receptor within the striatum and hypothalamus (Benarroch, 2012). In addition, the 3 subtypes of opioid receptors are expressed within the superficial laminae of the dorsal horn of the spinal cord, as well as the dorsal root ganglion, and the peripheral nociceptive neurons (Benarroch, 2012; Besse et al., 1990; Hassan et al., 1993; Stein et al., 1996). The distribution of opioids within the CNS is very similar to that of the receptors for the peptide hormone oxytocin.
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Present address: Department of Anatomy and Histology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.
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Present address: Department of Anesthesiology, Johns Hopkins Hospital, Baltimore, MD 21205, U.S.A.