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Cited by (70)
The locus coeruleus as a global model failure system
2024, Trends in NeurosciencesAge-dependent dysregulation of locus coeruleus firing in a transgenic rat model of Alzheimer's disease
2023, Neurobiology of AgingNeuropathic pain increases spontaneous and noxious-evoked activity of locus coeruleus neurons
2021, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :Microdialysis studies correlated this phasic activation with enhanced noradrenaline release in terminal areas like the spinal cord (Florin-Lechner et al., 1996), thereby promoting feedback inhibition of pain and contributing to analgesia (Pertovaara, 2006; Llorca-Torralba et al., 2016). In this sense, although the role of the LC modulating acute pain has been studied widely in healthy animals (Chiang and Aston-Jones, 1993; Hirata and Aston-Jones, 1994; Hirata and Aston-Jones, 1996), little is known about the noxious-evoked (phasic) discharge of this nucleus under conditions of neuropathic pain. Moreover, most studies in chronic pain have examined the tonic but not phasic LC activity.
Noradrenergic ensemble-based modulation of cognition over multiple timescales
2019, Brain ResearchCitation Excerpt :We overcame the technical challenges that have prevented simultaneous recordings of numerous LC single units in rats by implanting high-density, 32 channel multi-electrode recording arrays contained on a single, 15 µm thick (in coronal plane) silicone shank (Fig. 1), which minimized tissue damage (Totah et al., 2018). Typically, for extracellular recordings, a single electrode or small bundle of two, four, or sometimes eight wire electrodes are implanted in the LC so as to avoid damage of the small nucleus (Aghajanian et al., 1977; Arakawa et al., 1997; Aston-Jones et al., 1997; 1994; Aston-Jones and Bloom, 1981b,a; Aston-Jones et al., 1985; 1980; Bari and Aston-Jones, 2012; Bouret and Richmond, 2015; Bouret and Sara, 2004; Cedarbaum and Aghajanian, 1978a; Chen and Sara, 2007; Chiang and Aston-Jones, 1993; Clayton et al., 2004; Curtis et al., 1997; Ennis and Aston-Jones, 1986a; Eschenko et al., 2011; Eschenko and Sara, 2008; Faiers and Mogenson, 1976; Foote et al., 1980; Grant et al., 1988; Hervé-Minvielle and Sara, 1995; Hirata and Aston-Jones, 1994; Jodo et al., 1998; Joshi et al., 2016; Kalwani et al., 2014; Mana and Grace, 1997; Manohar et al., 2017; Marzo et al., 2014; Nakamura, 1977; Neves et al., 2018; Rajkowski et al., 2004, 1994; Sakaguchi and Nakamura, 1987; Sara and Hervé-Minvielle, 1995; Swick et al., 1994; Takeuchi et al., 2016; Uematsu et al., 2017; Usher et al., 1999; Valentino et al., 1991; Vankov et al., 1995; Varazzani et al., 2015). ( We have cited, to our knowledge, the majority of studies using such methods; note that many of these studies were in anesthetized animals or in vitro slice recordings, except for recordings from awake rats by Aston-Jones and Bloom (1981a,b), Bouret and Sara (2004), Curtis et al. (1997), Foote et al. (1980), Eschenko and Sara (2008); Hervé-Minvielle and Sara (1995); Manohar et al. (2017), Takeuchi et al. (2016), Uematsu et al. (2017) and Vankov et al. (1995) or recordings from awake primates by Aston-Jones et al. (1994, 1997), Bouret and Richmond (2015), Clayton et al. (2004), Foote et al. (1980), Grant et al. (1988), Joshi et al. (2016), Kalwani et al. (2014), Swick et al. (1994), Usher et al. (1999) and Varazzani et al. (2015)).