Elsevier

Neuroscience

Volume 68, Issue 1, September 1995, Pages 151-157
Neuroscience

Interleukin-1β induces long-term increase of axonally transported opiate receptors and substance P

https://doi.org/10.1016/0306-4522(95)00106-SGet rights and content

Abstract

Interleukin-1 is known to exert pleiotropic effects in host defence mechanisms and in inflammation. Chronic pain, inflammation and interleukin-1β enhance the production of substance P. Recently, axonal transport of opiate receptors was found to increase in rat sciatic nerves in the model of Freund's adjuvant-induced arthritis.

Here we show that a single intraplantar injection of interleukin-1β is able to enhance the axonal transport of μ and κ opiate receptors and substance P. Indeed, their accumulation was markedly increased in the proximal part of ligated sciatic nerves, but only in the paw injected with interleukin-1. The time course revealed a delayed onset and, more importantly, a long-term increase lasting at least six days, which is in contrast with the short-term pyrogenic effect of interleukin-1. Pretreatment of rats with capsacin or administration of dexamethasone completely prevented the interleukin-1β effect.

The present results suggest that interleukin-1β may serve as a mediator to sensitize nociceptors in chronic inflammation and possibly in hyperalgesia through long-term changes in neuronal plasticity.

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