Excitation of rat substantia nigra pars reticulata neurons by 5-hydroxytryptaminein vitro: Evidence for a direct action mediated by 5-hydroxytryptamine2C receptors
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Cited by (74)
Serotonergic control of excitability: from neuron to networks
2020, Handbook of Behavioral NeuroscienceThe role of the serotonergic system in motor control
2018, Neuroscience ResearchCitation Excerpt :In one study, both electrical stimulation of the DRN (Fibiger and Miller, 1977) and local administration of serotonin to the substantia nigra decreased firing rates of neurons in the substantia nigra pars compacta (Collingridge and Davies, 1981). In a similar study, however, administration of serotonin increased firing rate of neurons in the substantia nigra pars reticulata (Rick et al., 1995). Further detailed analysis showed that the effects of serotonin varied amongst neurons in the substantia nigra pars reticulata, where neurons were either inhibited through the 5-HT1B receptor or excited via the 5-HT2C receptor (Góngora-Alfaro et al., 1997).
The Substantia Nigra Pars Reticulata
2016, Handbook of Behavioral NeuroscienceCitation Excerpt :5-HT2CRs and 5-HT2ARs are coupled to Gq protein and phospholipase C, and 5-HT4Rs are coupled to Gs protein and adenylyl cyclase; hence these 5-HT receptors are generally excitatory (Hannon and Hoyer, 2008). Indeed, neurophysiological studies indicate that exogenous 5-HT, via activation of 5-HT2CRs, strongly excites SNr GABA neurons by inducing a linear inward current with a reversal potential around −30 mV (Rick et al., 1995; Stanford and Lacey, 1996; Zhou, unpublished data) (see also Fig. 15.7F). This inward current is accompanied by an increased whole cell conductance, and thus excluding closing of K channels as the underlying ionic mechanism, while indicating an opening of cation channels, potentially TRPC3 channels, that produces a next influx of cations (Zhou and Lee, 2011).
Serotonin in antipsychotic drugs action
2015, Behavioural Brain ResearchCitation Excerpt :In addition to the very high levels detected in the choroid plexus, 5-HT2C binding sites are widely distributed in cortical areas (olfactory nucleus, pyriform, cingulate and retrosplenial), limbic system (nucleus accumbens, hippocampus, amygdala), and the basal ganglia (caudate nucleus, substantia nigra) [54]. While the 5-HT2C receptors are clearly located postsynaptically, they might be also located presynaptically [64,68]. The pharmacological profile of the 5-HT2C receptor is close to, but discernible, from other members of the 5-HT2 receptor family [69].
Effects of noradrenaline and serotonin depletions on the neuronal activity of globus pallidus and substantia nigra pars reticulata in experimental parkinsonism
2012, NeuroscienceCitation Excerpt :Microiontophoretic injection of 5-HT into the SNr produced mixed, although mostly inhibitory, effects (Collingridge and Davies, 1981; Dray, 1981; Gongora-Alfaro et al., 1997). In spite of this evidence, Lacey and coworkers have shown that 5-HT not only directly excites SNr neurons but also disinhibits them by reducing GABA release from striatonigral terminals, acting on presynaptic 5-HT1B receptors (Rick et al., 1995; Stanford and Lacey, 1996). Furthermore, 5-HT2C receptor stimulation excites SNr neurons in vivo (Di Giovanni et al., 2001; Invernizzi et al., 2007).
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Present address: Department of Anesthesia and Critical Care, University of Chicago, Whitman Laboratory, 915 E57th Street, Room 207, Chicago IL 60637, U.S.A.