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2016, Basal GangliaCitation Excerpt :These results implicate the D2 receptor as the primary functional autoreceptor [224–227]. Nevertheless, biphasic suppression of DA release monitored using FCV in striatal slices is seen with a D3-selective agonist, 7-OH-DPAT, which provides evidence for D3- as well as D2-dependent DA release regulation [228]. This is supported by a study in striatal slices from D3-KO mice that suggested some role for D3 in regulation of secretion, but not synthesis [229].
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