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2016, Pharmacology and TherapeuticsCitation Excerpt :The effects of numerous non-selective agents on c-Fos expression could be related to the brain activation of 5-HT1BRs (Lucas et al., 1997b; Wirtshafter & Cook, 1998). Regarding c-Fos specifically, while 5-HT2CR stimulation strongly stimulates PLC activity in rat striatal slices (Wolf & Schutz, 1997), 5-HT2C agonists including Ro-60-0175 or DOI are poorly active on c-Fos expression (via 5-HT2CRs) and not only in the striatum (Leslie et al., 1993; Moorman & Leslie, 1996; Stark et al., 2006; Beyeler et al., 2010; Navailles et al., 2013b; Cathala et al., 2015). The preferential 5-HT2C agonist VER23779 has been shown to induce a strong signal in the basolateral nucleus of the amygdala (Somerville et al., 2007).
Brain pattern of histone H3 phosphorylation after acute amphetamine administration: Its relationship to brain c-fos induction is strongly dependent on the particular brain area
2012, NeuropharmacologyCitation Excerpt :It is also noteworthy that the highest induction of c-fos and increases in pH3S10 positive neurons were found in the ICjM. This ventral striatal region (Fallon et al., 1978) is a poorly studied structure that is greatly activated by different types of addictive drugs, including amphetamine derivatives (Moorman and Leslie, 1996; Stephenson et al., 1999) and appear to be involved in rewarding effects of electrical self-stimulation (Nakajima and Patterson, 1997) and sexual attraction (Lanuza et al., 2008). Our present data give support to an important role of ICjM in reward-related behaviours.
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