ArticleCRF antagonist partially reverses CRF- and stress-induced effects on feeding
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2019, NeuropeptidesHypothalamic mechanisms associated with corticotropin-releasing factor-induced anorexia in chicks
2019, NeuropeptidesCitation Excerpt :The CRF antagonist, α-helical CRF, attenuated the anorectic effects of CRF injection into the PVN but not other hypothalamic nuclei such as the ventromedial hypothalamus (VMH) (Kalra et al. 1999). Additionally, central injection of α-helical CRF augments NPY-induced hunger (Heinrichs et al. 1992), and blunts the reduction in food intake caused in response to restraint (Krahn et al. 1986) and tail pinch (Heinrichs et al. 1992) stress and exercise (Rivest and Richard 1990), which suggests that endogenous CRF plays a physiological role in appetite regulation. This is consistent with observations that endogenous CRF production is affected by a variety of factors that affect feeding behavior, including drugs such as fenfluramine (Appel et al. 1991), obesity (Richard et al. 1996), and tumor-induced anorexia (McCarthy et al. 1993).
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