Effects of three monoamine uptake inhibitors on behavior maintained by cocaine or food presentation in rhesus monkeys
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2019, Advances in PharmacologyCitation Excerpt :First, different approaches have been used to increase serotonergic activity. For example, preclinical studies with serotonin-selective reuptake inhibitors (SSRIs) have shown that increases in serotonergic activity can attenuate the rewarding or reinforcing effects of psychomotor stimulants such as amphetamine (Yu, Smith, Smith, & Lyness, 1986) and cocaine (Howell & Byrd, 1995; Kleven & Woolverton, 1993). However, effective doses of SSRIs tend to be relatively high, which leads to undesirable nonspecific behavioral effects that limit the clinical value of this approach.
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2017, Journal of Psychiatric ResearchCitation Excerpt :These results were consistent with those in previous reports where rats trained to self-administer food and then exposed to multiple extinction sessions showed a decrease in lever press responses (Aoyama et al., 2014; Krasnova et al., 2014). Other authors indicate that antidepressants do not change motivation for food (Kleven and Woolverton, 1993). This is in line with the results of this study, namely that animals previously trained to self-administer food and then dosed with mirtazapine during extinction had lever press responses similar to those in the FOOD + Vehicle group.
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2015, NeuroscienceCitation Excerpt :The β-carboline alkaloids indicate modest affinity to 5-HT, dopamine and benzodiazepine receptors (Glennon et al., 2000). These alkaloids influence central neurotransmitters such as dopamine (Moura et al., 2006; Nasehi et al., 2010, 2012), via inhibition of monoamine reuptake systems (Kleven and Woolverton, 1993; Baum et al., 1996; Yang et al., 2011), and inhibition MAO-A or B (Glennon et al., 2000; Touiki et al., 2005). Some evidences displayed that harmaline change the extracellular and tissue level of dopamine (Kim et al., 1970; Glick et al., 1994, 1996).
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2014, Advances in PharmacologyCitation Excerpt :Preclinical studies have clearly indicated that serotonin plays an important role in the behavioral effects of cocaine. Acute administration of SERT inhibitors attenuates the behavioral-stimulant effects of cocaine in squirrel monkeys (Howell & Byrd, 1995; Howell, Czoty, & Byrd, 1997) and decreases cocaine self-administration in rodents (Carroll, Lac, Asencio, & Kragh, 1990) and nonhuman primates (Czoty, Ginsburg, & Howell, 2002; Kleven & Woolverton, 1993). The SERT inhibitor alaproclate also attenuated cocaine-induced increases in extracellular dopamine in squirrel monkeys (Czoty et al., 2002) and cocaine-induced activation of prefrontal cortex in rhesus monkeys (Howell et al., 2002).
Involvement of dopamine D<inf>1</inf>/D<inf>2</inf> receptors on harmane-induced amnesia in the step-down passive avoidance test
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2010, Pharmacological ReportsCitation Excerpt :Second, what could be the mechanism responsible for this effect of 1MeTIQ? The behavioral effect of acute cocaine is closely related to the increase in dopamine concentration in the synaptic cleft associated with dopamine transporter (DAT) inhibition [34, 46, 70, 82] and the activation of dopamine D1 [86] and D2 receptors [17, 26, 28, 67]. In humans, a significant correlation has been observed between DAT occupancy and the intensity of the subjective effects produced by intravenous cocaine [79]; dopamine antagonists attenuate the behavioral effects of cocaine [16, 32, 83].