Elsevier

Toxicology Letters

Volume 44, Issues 1–2, November 1988, Pages 47-54
Toxicology Letters

Physiological antioxidants and antioxidative enzymes in vitamin E-deficient rats

https://doi.org/10.1016/0378-4274(88)90128-2Get rights and content

Abstract

The effects of feeding vitamin E-deficient diets to rats for one year were investigated to analyse the relationship of the vitamin with other antioxidants and some antioxidative enzymes. Long-term vitamin E deficiency lowered the levels of antioxidants like vitamin E, ascorbic acid and glutathione (GSH) in all tissues analysed and thus increasing the extent of tissue peroxidisability. Vitamin E deficiency had also influenced the activities of superoxide dismutase (SOD), catalase and glutathione peroxidase, the enzymes that are involved in detoxification mechanisms of products arising from free radical metabolism.

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