Elsevier

Toxicology Letters

Volume 85, Issue 3, June 1996, Pages 165-171
Toxicology Letters

Research article
Sex-related differences in the effect of aluminum on calcium transport in the small intestine of the rat

https://doi.org/10.1016/0378-4274(96)03659-4Get rights and content

Abstract

Everted sacs of distinct segments of small intestine from male and female rats were incubated with 2 μM of aluminum (Al). In duodenum, Al significantly diminished calcium flux (JCams) in cycling females (31%, P < 0.01) and in males (17%, P < 0.05). Incubation under anaerobic conditions nullified the inhibition of Al on JCams both in male and in female duodenal sacs. Jejunal and ileal JCams measured under aerobic conditions were not modified by the presence of Al in mucosal fluid compared to Al-free controls, neither in males nor in cycling females. In ovariectomized female rats treated with estrogen the studies of dose-response curves showed that the sensitivity to the effect of Al on JCams was raised (the dose that produced half maximum response diminished) with increasing 17β-estradiol serum levels, without changes in the maximum response. In castrated male rats injected with testosterone, the effect of Al on duodenal JCams was found to be independent of testosterone levels. In summary, our results demonstrated that the Al inhibition on duodenal JCams was influenced by sexual hormone levels in females but was independent of them in males.

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