Ethanol may stimulate or inhibit (Na+ + K+)-ATPase, depending upon Na+ and K+ concentrations

doi:10.1016/0741-8329(89)90048-7

Alcohol

Volume 6, Issue 6, November–December 1989, Pages 437-443

https://doi.org/10.1016/0741-8329(89)90048-7 Get rights and content

Abstract

The influence of varying the ratios of [Na⁺]/[K⁺] on the effects of alcohol (500 mg/dl) on brain (Na⁺ + K⁺)-ATPase, using a commercial porcine enzyme preparation, showed that, generally, activity was stimulated by ethanol when [Na⁺] < [K⁺], but inhibited when [Na⁺] > [K⁺] (with sum kept constant at 150 mM). In addition, when [Na⁺]/[K⁺] was $1590 mM$ , representative of normal intracellular levels, ethanol (500 mg/dl) stimulated the porcine enzyme, but inhibited it when [Na⁺]/[K⁺] was $1446 mM$ , representative of normal extracellular levels. Similarly, in freshly prepared enzyme from highly purified rat brain synaptic membranes, ethanol (100, 300, and 450 mg/dl) stimulated when [Na⁺]/[K⁺] was $1588 mM$ (representing intracellular levels), but inhibited when [Na⁺]/[K⁺] was $1424 mM$ (extracellular levels).

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ArticleEthanol may stimulate or inhibit (Na+ + K+)-ATPase, depending upon Na+ and K+ concentrations

Abstract

J. Biol. Chem.

Biochim. Biophys. Acta

J. Biol. Chem.

Biochim. Biophys. Acta

Biochim. Biophys. Acta

J. Biol. Chem.

J. Magn. Reson.

Biochim. Biophys. Acta

Biochem. Pharmacol.

Biochim. Biophys. Acta

Eur. J. Pharmacol.

Biochem. Pharmacol.

Brain Res.

Biochim. Biophys. Acta

Biochem. Biophys. Res. Commun.

Anal. Biochem.

J. Biol. Chem.

J. Biol. Chem.

Pharmacol. Biochem. Behav.

Biochim. Biophys. Acta

J. Biol. Chem.

J. Biol. Chem.

J. Biol. Chem.

J. Theor. Biol.

Article
Ethanol may stimulate or inhibit (Na⁺ + K⁺)-ATPase, depending upon Na⁺ and K⁺ concentrations