Diazepam binding inhibitor processing in the rhesus monkey brain: An immunocytochemical study
References (27)
Electrophysiology of GABAA and GABAB receptor subtypes
Trends Neurosci.
(1988)- et al.
Distribution and characterization of diazepam binding inhibitor (DBI) in peripheral tissues of rat
Regulatory Peptides
(1990) - et al.
Diazepam binding inhibitor (DBI): A peptide with multiple biological actions
Life Sci.
(1991) - et al.
Co-localization and co-release of GABA and putative allosteric modulators of GABA receptor
Neuropharmacology
(1987) - et al.
A brain octadecaneuropeptide generated by tryptic digestion of DBI (diazepam binding inhibitor) functions as a proconflict ligand of benzodiazepine recognition sites
Neuropharmacology
(1984) - et al.
A diazepam binding inhibitor (DBI)-like neuropeptide is detected in human brain
Brain Res.
(1986) - et al.
A study of diazepam binding inhibitor (DBI) processing products in human cerebrospinal fluid and in postmortem human brain
Neuropharmacology
(1990) A new solid-state reagent to iodinate proteins
Anal. Biochem.
(1982)- et al.
Isolation and characterization of a putative endogenous benzodiazepine (endozepine) from bovine and human brain
J. Biol. Chem.
(1986) - et al.
Immunocytochemical localization of the endogenous benzodiazepine ligand octadecaneuropeptide (ODN) in the rat brain
Neuropeptides
(1990)
Diazepam-binding inhibitor: A neuropeptide located in selected neuronal populations of rat brain
Science
Cellular and subcellular location of an octadecaneuropeptide derived from diazepam binding inhibitor: immunohistochemical studies in the rat brain
J. Chem. Neuroanat.
Diazepam binding inhibitor (DBI) processing: immunohistochemical studies in the rat brain
Neurochem. Res.
Cited by (20)
Neuropeptidergic control of neurosteroids biosynthesis
2022, Frontiers in NeuroendocrinologyCitation Excerpt :DBI mRNA is expressed in glial cells in the central nervous system of mammals (Alho et al., 1988; Tong et al., 1991; Bürgi et al., 1999). Immunocytochemistry for endozepines localized them in astrocytes in the arcuate nucleus, ependymocytes lining the third ventricle, tanycytes in the median eminence, pituicytes in the neurohypophysis, and Bergman cells in the cerebellum in rats, monkeys, and humans (Slobodyansky et al., 1992; Malagon et al., 1993; Alho et al., 1995; Yanase et al., 2002). DBI mRNA and ODN-ir materials were localized in radial glial cells of the periventricular systems of the diencephalon and rhombencephalon in the frog R. esculenta (Malagon et al., 1992a; Lihrmann et al., 1994).
Endozepines and their receptors: Structure, functions and pathophysiological significance
2020, Pharmacology and TherapeuticsCitation Excerpt :It should be noticed however that the latter researchers, using in situ hybridization, later observed DBI mRNA expression in glial cells and tanycytes (Alho et al., 1988). In contrast, in the Rhesus monkey brain, Slobodyansky and colleagues reported that an antiserum against purified rat DBI labeled astrocytes whereas antisera against synthetic ODN or TTN stained neurons (Slobodyansky et al., 1992). Although the origin of this discrepancy is not elucidated, it is conceivable that the antibodies against purified DBI used by Alho and colleagues and the antibodies against synthetic ODN or TTN used by Slobodyansky and colleagues cross-reacted with related peptides.
Endozepines
2015, Advances in PharmacologyCitation Excerpt :The role for different transcripts in the different putative functions of DBI (fatty acid metabolism and modulation of GABAAR signaling) remains unclear. DBI has a number of putative endoprotease sites and several cleavage products including triakontatetraneuropeptide (TTN, DBI(17–50)), octadecaneuropeptide (ODN, DBI(33–50)), and octapeptide (OP, DBI(43–50)) (Ferrero, Santi, Conti-Tronconi, Costa, & Guidotti, 1986) which have been identified in rat and rhesus monkey CNS (Alho et al., 1989, 1991; Slobodyansky, Kurriger, & Kultas-Ilinsky, 1992) and all demonstrate the ability to displace BZs and modulate inhibition via allosteric modulations of the GABAAR. The majority of evidence for the action of DBI peptides at GABAARs suggests negative allosteric modulation.
Endogenous Positive Allosteric Modulation of GABA<inf>A</inf> Receptors by Diazepam binding inhibitor
2013, NeuronCitation Excerpt :DBI mRNA is widely expressed throughout the brain, including the thalamus (Lein et al., 2007). Previous immunohistochemical studies have observed varying profiles of protein expression for DBI and fragment peptides in the CNS of various species (Tonon et al., 1990; Slobodyansky et al., 1992; Lihrmann et al., 1994), likely due to use of different antisera and other methodological differences, but in some cases higher expression was observed in nRT (Alho et al., 1985, 1989). We therefore hypothesized that DBI may exert endogenous effects within the thalamus, thereby modulating seizure susceptibility.
Endozepines
2013, Handbook of Biologically Active Peptides