Oxygen radicals: Common mediators of neurotoxicity

doi:10.1016/0892-0362(91)90081-7

Neurotoxicology and Teratology

Volume 13, Issue 3, May–June 1991, Pages 341-346

https://doi.org/10.1016/0892-0362(91)90081-7 Get rights and content

Abstract

The inherent biochemical, anatomical and physiological characteristics of the brain make it especially vulnerable to insult. Specifically, some of these characteristics such as myelin and a high energy requirement provide for the introduction of free radical-induced insult. Recently, the biochemistry of free radicals has received considerable attention. It also has become increasingly apparent that many drug and chemical-induced toxicities may be evoked via free radicals and oxidative stress. Major points addressed in this work are the regulation of neural free radical generation by antioxidants and protective enzymes, xenobiotic-induced disruption of cerebral redox status, and specific examples of neurotoxic agent-induced alterations in free radical production as measured by the fluorescent probe dichlorofluorescein. This article considers the thesis that free radical mechanisms may contribute significantly to the properties of several diverse neurotoxic agents and proposes that excess production of free radicals may be common phenomena of neurotoxicity.

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MinireviewOxygen radicals: Common mediators of neurotoxicity

Abstract

Fundam. Appl. Toxicol.

Free Rad. Biol. Med.

Arch. Biochem. Biophys.

Neurosci. Lett.

Free Rad. Biol. Med.

Trends Neurosci.

Arch. Biochem. Biophys.

Biochim. Biophys. Acta

Free Rad. Biol. Med.

Toxicology

Biochim. Biophys. Acta

Toxicol. Appl. Pharmacol.

Toxicol. Appl. Pharmacol.

Biochem. Pharmacol.

Biochem. Biophys. Res. Commun.

Neurochem. Int.

Int. J. Dev. Neurosci.

Toxicol. Appl. Pharmacol.

Chem. Biol. Interact.

Neuron

Neurosci. Lett.

Brain Res.

Neurosci. Lett.

Neurosci. Lett.

Free Rad. Biol. Med.

Arch. Biochem. Biophys.

Arch. Biochem. Biophys.

Toxicol. Appl. Pharmacol.

J. Biol. Chem.

Environ. Res.

Oxidative effects of MPTP in the midbrain

Res. Comm. Sub. Abuse

Triethyl lead-induced damage in various regions of the rat brain

J. Toxicol. Environ. Health

Cerebral superoxide anion generation during seizures in newborn pigs

J. Cereb. Blood Flow Metab.

Role of metals in oxygen radical reactions

J. Free Rad. Biol. Med.

Minireview
Oxygen radicals: Common mediators of neurotoxicity