Distribution of prescription drug exposures in the elderly: Description and implications☆
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Cited by (48)
Safety and Clinical Outcomes of Abiraterone Acetate after Docetaxel in Octogenarians with Metastatic Castration-Resistant Prostate Cancer: Results of the Italian Compassionate Use Named Patient Programme
2016, Clinical Genitourinary CancerCitation Excerpt :It is also a substrate of CYP3A4, increasing the risk of drug–drug interactions in patients taking it at the same time as strong CYP3A4 inhibitors (eg, fluconazole or erythromycin) or inducers such as carbamazepine, phenytoin, or rifampicin. Because patients aged > 75 years are generally exposed to a median of 3.8 different drugs (compared with 2.2 in those aged 65-74 years) and because 37% take as many as ≥ 6 (compared with 22% of those aged 65-74 years), the risk of adverse events from drug–drug interactions can be particularly significant in very elderly patients.20 In our patients, the incidence of comorbidities was mostly not different from that of the younger counterparts, highlighting patient selection by the comorbidity burden more than by a simple age-based criterion.
Missions and organization of mobile psychiatric teams for the elderly: The example of the mobile psychiatric team for the elderly (EMPPA Ouest 94), Paul Guiraud Hospital, Villejuif
2015, NPG Neurologie - Psychiatrie - GeriatrieSystematic review of factors affecting pharmaceutical expenditures
2014, Health PolicyCitation Excerpt :There was methodological variation in the studies’ exploration of the factors affecting pharmaceutical expenditures. The methods include: analysis of prescription claims [13] and the structural effect approach [14]; decomposition of pharmaceutical spending growth [15]; dynamics of expenditure through time [16]; decomposition of change in real drug spending using a multiplicative growth equation [17]; decomposition of real drug spending into price, quantity and residual [18,19]; prescription drug expenditures [20–22]; decomposing the growth of pharmaceutical expenditures into three components: treatment expansion; treatment substitution; and price effect [23]; a pharmacoepidemiological model based on incidence, treatment discontinuation and drug user mortality [24];decomposition of the increase in real drug expenditures into a price effect, a volume effect, and a product-mix effect [25]; multiplicative factor equations using index numbers [26–29]; and equations describing changes in age/sex-specific expenditures [30]. Other studies included trend analysis [31–36] and fixed effects using regression analysis and the demographic impact method [37].
Psychiatry in the elderly: Issues and prospects
2014, Annales Medico-PsychologiquesAcquisition cost of dispensed drugs in individuals with multiple medications-A register-based study in Sweden
2011, Health PolicyCitation Excerpt :To a large extent, the two groups include the same individuals [35] and the costs of drug therapy have been used to screen patients for a community pharmacy-based medication review program [36]. Although previous studies have mainly focused on patients with the highest drug cost and not on individuals with multiple medications, our findings that the overall drug costs are concentrated on a relatively small proportion of the population are in agreement with previous findings [33–35,37,38]. Furthermore, the observed female–male ratio (60:40) is in line with a previous report [35].
Age-related modifications in CYP-dependent drug metabolism: role of stress
2023, Frontiers in Endocrinology
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This study was funded under a grant from Health and Welfare Canada (NHRDP6610-1774-57). Dr. Anderson also received personal support from Health and Welfare Canada (NHRDP-6610-1737-48).