Neuron
Volume 3, Issue 6, December 1989, Pages 715-720
ArticleSynaptic vesicles immunoisolated from rat cerebral cortex contain high levels of glutamate
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2021, NeuropharmacologyCitation Excerpt :Notably, glutamate transport into these vesicles is considered a critical step in diverting glutamate from its metabolic role to its neurotransmitter function. It has been estimated that glutamate can reach intravesicular concentrations of 60 mM in vivo (Burger et al., 1989) while the cytosolic glutamate concentration is approximately 5–10 mM (Danbolt, 2001; Featherstone and Shippy, 2008). The mechanism for glutamate storage into synaptic vesicles involves an energy-dependent system coupling glutamate accumulation with ATP hydrolysis (Naito and Ueda, 1985; Ozkan and Ueda, 1998).
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