Neuron
ArticleA novel K+ channel with unique localizations in mammalian brain: Molecular cloning and characterization
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High spatial density is associated with non-conducting Kv channels from two families
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2014, Experimental NeurologyKv2 dysfunction after peripheral axotomy enhances sensory neuron responsiveness to sustained input
2014, Experimental NeurologyCitation Excerpt :In many neurons, delayed rectifying currents due to Kv2 conductance (Guan et al., 2007; Malin and Nerbonne, 2002; Murakoshi and Trimmer, 1999) are a key modulator of excitability by facilitating AP repolarisation and inter-spike hyperpolarisation during repetitive firing (Blaine and Ribera, 2001; Johnston et al., 2010; Malin and Nerbonne, 2002). The Kv2 family consists of the Kv2.1 and Kv2.2 subunits (Frech et al., 1989; Hwang et al., 1992; Swanson et al., 1990). In the central nervous system (CNS) Kv2.1 features activity-dependent localisation and function (Misonou et al., 2004; O'Connell et al., 2010) and has a paramount role in regulating somatodendritic excitability, especially during high frequency input (Du et al., 2000; Misonou et al., 2005).
Neuronal trafficking of voltage-gated potassium channels
2011, Molecular and Cellular NeuroscienceCitation Excerpt :Although the PRC sequence is well conserved in Kv2.2 (Lim et al., 2000), it was reported that the two Kv2 channel members exhibit very distinct subcellular distributions in mammalian neurons; Kv2.1 in proximal dendrites and Kv2.2 in more distal dendrites without clustering (Hwang et al., 1993; Lim et al., 2000). The apparent contradiction was solved recently by the discovery that the rat Kv2.2 cDNA sequence used in previous studies (Hwang et al., 1992) is a truncated version of a novel and predominant form of Kv2.2 (Kv2.2long). Kv2.2long shows a high degree of colocalization with Kv2.1 clusters in cortical pyramidal neurons (Kihira et al., 2010), thereby supporting the role of PRC as a targeting signal in Kv2.
A new Kv1.2 channelopathy underlying cerebellar ataxia
2010, Journal of Biological ChemistryCitation Excerpt :Voltage-gated potassium channels play a key role in neuronal excitability and plasticity and are critical in establishing resting membrane potential and firing thresholds, repolarizing action potentials, and limiting excitability (1). Channels are unevenly distributed throughout the brain as a whole and also within individual neurons (2–10). Therefore, the particular utility of any given channel depends not only on its specific channel properties and stoichiometry but also on its particular localization and density within a cell or cellular compartment.