Neuron
ArticleMolecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide
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Cited by (255)
Pituitary adenylate cyclase-activating peptide (PACAP) and its receptors in Mus musculus testis
2020, General and Comparative EndocrinologyPituitary adenylate cyclase-activating polypeptide (PACAP) in stress, pain, and learning
2020, Handbook of Behavioral NeuroscienceCitation Excerpt :PACAP is widely expressed throughout the periphery and central nervous system, and within the brain PACAP-38 is the predominant form (Arimura et al., 1991; Miyata et al., 1989; Miyata et al., 1990; Piggins, Stamp, Burns, Rusak, & Semba, 1996; Vaudry et al., 2009). PACAP influences cellular function through G-protein-coupled receptors: the PACAP receptor type I (PAC1R), which is highly selective for PACAP, and through VIP receptors (VPAC1 and VPAC2), which can be activated by PACAP or VIP (Harmar et al., 1998; Hashimoto, Ishihara, Shigemoto, Mori, & Nagata, 1993; Ishihara, Shigemoto, Mori, Takahashi, & Nagata, 1992; Lutz, Shen, Mackay, West, & Harmar, 1999). PACAP has been described as the “master regulator” of the stress response, based on its role in stimulating the biosynthesis of corticotropin-releasing factor in the hypothalamus (Hashimoto, Shintani, & Baba, 2006; Mustafa, 2013; Stroth, Holighaus, Ait-Ali, & Eiden, 2011).
Role of endogenous pituitary adenylate cyclase activating polypeptide (PACAP) in myelination of the rodent brain: Lessons from PACAP-deficient mice
2011, International Journal of Developmental NeuroscienceThe role of PACAP in central cardiorespiratory regulation
2010, Respiratory Physiology and NeurobiologyPituitary adenylate cyclase-activating polypeptide (PACAP)/PAC <inf>1</inf>HOP1 receptor activation coordinates multiple neurotrophic signaling pathways: Akt activation through phosphatidylinositol 3-kinase γ and vesicle endocytosis for neuronal survival
2010, Journal of Biological ChemistryCitation Excerpt :Two α-amidated forms of PACAP arise from alternative post-translational processing of the 175-amino acid rat precursor molecule; PACAP38 has 38 amino acid residues (proPACAP-(131–168)), whereasPACAP27 corresponds to the amino terminus of PACAP38 (proPACAP-(131–157)). As PACAP and VIP appear to stem from the same molecular cladistic tree during evolution (1), the two peptides not only share considerable structural homology but also function through three distinct G protein-coupled receptors (2–8). Only PACAP peptides exhibit high affinity for the PAC1 receptor, whereas VIP and PACAP have similar high affinities for the VPAC1 and VPAC2 receptors.
Hypothalamic PACAP/PAC1R Involvement in Feeding and Body Weight Regulation
2023, Endocrinology (United States)
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Present address: DNA Research Center, National Institute of Genetics, Mishima, Shizuoka 411, Japan.