Analogues of the thrombin receptor tetrered-ligand enhance mesangial cell proliferation
References (45)
- et al.
Blood
(1983) - et al.
Exp. Cell Res.
(1976) - et al.
Cell
(1991) - et al.
Biochim. biophys. Res. Commun.
(1991) - et al.
Biochim. biophys. Res. Commun.
(1992) - et al.
J. biol. Chem.
(1992) - et al.
Biochim. biophys. Res. Commun.
(1992) J. biol. Chem.
(1992)- et al.
Biochim. biophys. Res. Commun.
(1991) - et al.
Eur. J. Pharmac.
(1992)
J. biol. Chem.
Kidney Int.
Biochem. Pharmac.
FEBS Lett.
J. clin. Invest.
Biochem. J.
J. Cell. Physiol.
J. clin. Invest.
J. Cell. Biol.
Biochem. J.
J. Immunol.
J. biol. Chem.
Cited by (8)
The role of protease-activated receptor-1 in bone healing
2005, American Journal of PathologyCitation Excerpt :The remaining possibility is that thrombin, through PAR-1, stimulates BMSC proliferation. Previous studies have shown that thrombin is a mitogen for many cell types, including vascular smooth muscle cells,36,37 fibroblasts,38,39 endothelial cells,40 mesangial cells41 and osteoblasts.4 In many of these cells, proliferation is known to be mediated by PAR-1 and in osteoblasts, in particular, we have recently confirmed that proliferation is mediated by PAR-1.5
Thrombin is a novel regulator of hexokinase activity in mesangial cells
2000, Kidney InternationalCitation Excerpt :The ability of recombinant leech hirudins—specific inhibitors of thrombin's proteolytic activity—to prevent this increase in HK activity suggests specificity for thrombin and is compatible with the observation that thrombin's cellular effects are largely mediated by proteolytic activation of cell surface thrombin receptors22. The ability of oligopeptide PAR1 agonists (for example, HsPAR142/55 and HsPAR150/55)43,45 to mimic this effect suggests specificity for the PAR1 thrombin receptor. Three distinct PARs—PAR1, PAR3, and PAR4—that are specifically activated by thrombin have recently been cloned and characterized20,47,48.
PAR-2 elicits afferent arteriolar vasodilation by NO-dependent and NO-independent actions
2002, American Journal of Physiology - Renal PhysiologyProteinase-activated receptors
2001, Pharmacological ReviewsProteinase-activated receptors: Novel mechanisms of signaling by serine proteases
1998, American Journal of Physiology - Cell Physiology