European Journal of Pharmacology: Molecular Pharmacology
Comparative effects of GLP-1-(7-36) amide, oxyntomodulin and glucagon on rabbit gastric parietal cell function
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The physiological role of GLP-1 in human: Incretin, ileal brake or more?
2005, Regulatory PeptidesBiological actions and therapeutic potential of the glucagon-like peptides
2002, GastroenterologyCitation Excerpt :GLP-1 infusion inhibits sham feeding–induced acid secretion in normal human subjects,49–51 and these actions on acid secretion are dependent on both somatostatin receptor activation and intact gastric vagal innervation.52,53 GLP-1 receptor mRNA transcripts and GLP-1 binding have also been observed in purified rat and rabbit gastric parietal cell populations.54,55 In contrast, GLP-1 inhibits human gastric lipase secretion in a vagal nerve-independent manner.56
Gut hormones as pharmaceuticalsFrom enteroglucagon to GLP-1 and GLP-2
2000, Regulatory PeptidesCitation Excerpt :Because it is also present in very low concentrations in plasma under normal conditions, it is unlikely to exert glucagon-like effects in vivo, even if it is, like glucagon, strongly insulinotropic and activates hepatocyte adenylate cyclase activity. Like glucagon, it inhibits gastric acid secretion [18], but it has also been reported to interact with the GLP-l receptor (explaining the original proposal that it could have specific gastric receptors distinct from the glucagon receptors) [19]. It cannot be excluded that it may act as one of the enterogastrones of the ileal brake mechanism (the endocrine inhibition of upper GI functions elicited by the presence of nutrients in the ileum), but its role is probably minor because of its limited potency and low concentration.
What is the role of gastric glucagon-like peptide 1 ?
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