Functional relevance of presynaptic muscarinic autoreceptors

https://doi.org/10.1016/0928-4257(93)90001-AGet rights and content

Abstract

Pre- and postsynaptic muscarinic receptors have been characterized in the isolated trachea and ileal circular muscle of the guinea pig. The muscarinic autoreceptors mediating inhibition of acetylcholine release in the circular muscle belong to the M1 subtype, whereas those inhibiting acetylcholine release in the trachea are M2 or M4 receptors. In both tissues the postsynaptic muscarinic receptors are M3 receptors. Blockade of the autoreceptors by selective M1 and M2/M4 receptor antagonists leads to facilitation of cholinergic neurotransmission.

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Cited by (18)

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    Citation Excerpt :

    The effective hydrolysis of released acetylcholine favors the conclusion that acetylcholine does not only play a trophic but a regulatory or communicating role comparable to that in neurons. Nevertheless, in contrast to neurons the release in the present experiments was not modulated by nicotinic or muscarinic autoreceptors, which are well established regulatory mechanisms within the peripheral and central cholinergic nervous systems (Wessler, 1992; Kilbinger et al., 1993). The missing effects of atropine and tubocurarine may be explained by the assumption that murine embryonic stem cells do not express functional nicotinic or muscarinic receptors.

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