Review article
Remifentanil: A new opioid

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      The contraindications and utility of these agents in special populations to decrease side effects would further ensure safe and efficacious use. In particular, the short-acting opioid remifentanil with its rapid onset and offset, decreased accumulation, and easy titration make it an attractive drug for improving the overall patient experience when used in combination with hypnotic agents [53]. Other advantages, in particular with remifentanil, include decreased hemodynamic side effects, and neurohumoral stress response to surgery [66].

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      Regarding variables obtained before stimulation, only Ceremi, NIAPsys, and HR but not SSI showed predictive power concerning a defined response, like movement, after stimulation. These findings were expected for Ceremi, as increasing remifentanil concentration reduces MAC.21 Regarding the predictive power of HR and NIAPsys, we suggest that HR and NIAPsys were most probably reduced by increasing Ceremi.

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