Synthesis of novel iodinated radioligands with high affinity and selectivity for CCK-B/gastrin receptors

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Abstract

The syntheses of two non-peptide radio-iodinated ligands [125I]-PD142308 and [125I]-PD142251 with high affinity and selectivity for the CCK-B/gastrin receptor are described via a route which introduces the radiolabel at the final or penultimate step. The CCK-A and CCK-B binding affinities of both ligands are described.

The syntheses and binding characteristics of two non-peptide radio-iodinated ligands, PD-142308 and PD-142251, both with high affinity and selectivity for the CCK-B/gastrin receptor are described.

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References (20)

  • J.R. Pisegna et al.

    Biochem. Biophys. Res. Commun.

    (1992)
  • J. Denyer et al.

    Eur. J. Pharmacol.

    (1994)
  • D. Hill et al.

    Biomed. Chem. Lett.

    (1993)
  • H. Bayley et al.

    Tett. Lett.

    (1978)
  • G.N. Woodruff et al.

    Annu. Rev. Pharmacol. Toxicol.

    (1991)
  • B.E. Evans

    Drugs of the Future

    (1989)
  • D.C. Horwell et al.

    J. Med. Chem.

    (1991)
  • R.S.L. Chang et al.

    Mol. Pharmacol.

    (1989)
  • J.C. Hunter et al.

    Mol. Pharmacol.

    (1993)
  • C. Hansch et al.
There are more references available in the full text version of this article.

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