Brief review
The 3β-hydroxysteroid dehydrogenase gene family of enzymes

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Abstract

It now is apparent that a family of closely related genes encode for 3β- hydroxysteroid dehydrogenase (3βHSD). Studies on the regulation of these genes are in their infancy, but the regulation appears multifactorial. The various 3βHSD genes are expressed principally in a tissue-specific manner likely involving separate mechanisms of regulation. To date, two human 3βHSD genes and their products have been characterized; type I is expressed in placenta, sebaceous glands, and several other nonendocrine tissues, whereas the type II isoform is the principal 3βHSD of adrenal cortex and gonads.

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