Original ArticlesSignificance of P53 and Rb protein expression in surgically treated non-small cell lung cancers
Section snippets
Lung cancer patients and specimens
Two hundred and seven lung cancer specimens were obtained from patients who underwent surgical resection for NSCLC at the National Taiwan University Hospital during the period from January 1990 through December 1994. All of the specimens were formalin fixed and sectioned for microscopic examination after staining with hematoxylin-eosin. Histological diagnosis and pathological features were obtained including tumor cell type, degree of differentiation, vascular invasion or emboli, regional lymph
Results
In the current study, P53 nuclear staining was detected in 115 of the 207 lung tumors (56.7%). The relationship of clinical parameters of the patients with the presence of P53 expression is shown in Table 1. A borderline significance of higher positive rate of P53 expression was noted in lung cancer patients with age under 45 years. There was no significant difference of P53 expression in relation to gender, smoking status, tumor location, or multiplicity of the tumor. Compared with various
Comment
It is well documented that specific genetic alteration and aberrant gene expression in tumor cells may influence the biological behaviors of a tumor 2, 6. P53 is a tumor suppressor gene, involved in cell cycle control and preservation of genomic integrity 2, 5. Alteration of the p53 gene may be involved in the initiation, development, progression, and invasion of lung cancer 6, 8, 10, 11. The correlation of p53 protein expression with clinical and biological characteristics of lung cancer has
Acknowledgements
This study was supported by research grant NSC-86-2314-B002-045 from the National Science Council, ROC.
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