Volatile anesthetics selectively alter [3H]ryanodine binding to skeletal and cardiac ryanodine receptors1

https://doi.org/10.1016/S0006-291X(05)80850-2Get rights and content

Summary

The effect of clinical concentrations of volatile anesthetics on ryanodine receptors of cardiac and skeletal muscle sarcoplasmic reticulum was evaluated using [3H]ryanodine binding. At 2 volume percent, halothane and enflurane stimulated binding to cardiac SR by 238% and 204%, respectively, while isoflurane had no effect. In contrast, halothane and enflurane had no effect on [3H]ryanodine binding to skeletal ryanodine receptors, while isoflurane produced a significant stimulation. These results suggest that volatile anesthetics interact in a site-specific manner with ryanodine receptors of cardiac or skeletal muscle to effect Ca2+ release-channel gating.

References (18)

  • MeissnerG

    J Biol Chem

    (1986)
  • OtsuK et al.

    J Biol Chem

    (1990)
  • BrownBR et al.

    Anesthesiology

    (1971)
  • RusyBF et al.

    Anesthesiology

    (1987)
  • PessahIN et al.

    Mol Pharmacol

    (1991)
  • MickelsonJR et al.

    J Biol Chem

    (1988)
  • MeissnerG

    J Biol Chem

    (1983)
  • FabiatoA

    Am J Physiology

    (1983)
  • McPhersonPS et al.

    Neuron

    (1991)
There are more references available in the full text version of this article.

Cited by (25)

View all citing articles on Scopus
1

Supported by International Anesthesia Research Society, NIH (GM 36852), American Heart Association, and Muscular Dystrophy Association.

View full text