Biochemical and Biophysical Research Communications
Photoaffinity labelling and phosphorylation of a 165 kilodalton peptide associated with dihydropyridine and phenylalkylamine-sensitive calcium channels
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Calcium Signaling in Neurons and Glial Cells: Role of Cav1 channels
2019, NeuroscienceCitation Excerpt :Each of the four domains consists of six putative transmembrane α-helical segments (S1 to S6) with the S4 segment of each homologous domain serving as the voltage sensors responsible for activation, moving outward or inward under the influence of membrane potential changes (Fig. 1). The S5 and S6 segments form the pore-lining of the CaV channels (Hosey et al., 1987; Takahashi et al., 1987; Tanabe et al., 1987; Ellis et al., 1988). The different types of Ca2+ currents are primarily defined by ten different α1 subunits in mammalian cells.
Finding channels
2015, Journal of Biological ChemistryCitation Excerpt :Finally, the γ subunit was both hydrophobic and glycosylated, so we placed it in a transmembrane position in the complex. We were stunned by the complexity of this calcium channel architecture, but we were quickly reassured that the results and model were correct as parallel work from the laboratories of Kevin Campbell (University of Iowa), Joerg Striessnig and Hartmut Glossmann (University of Innsbruck), Michel Lazdunski, and Franz Hofmann provided independent support for specific elements of the overall calcium channel model (28–32). The team of scientists in my laboratory that identified, purified, reconstituted, and defined the subunit structure of sodium and calcium channels was small and close-knit.
Metabolic syndrome and ionic channels in pancreatic beta cells
2014, Vitamins and HormonesCitation Excerpt :VDCCs were first classified according to their voltage activation in low-voltage-activated type T channels (approximately − 60 mV) or high-voltage-activated (HVA, approximately − 30 mV) that included types L (long lasting), N (neuron), P/Q (first recorded in Purkinje neurons), and R channels (Fig. 4.3). The initial purification studies revealed alpha1, beta, and gamma subunits (Catterall, 2000b) and later biochemical analyses revealed an additional alpha2-delta subunit that comigrated with alpha1 (Hosey et al., 1987). Calcium channels are heteromeric complexes composed of alpha1, beta, alpha2-delta, and gamma subunits.
Effects of 1,25-Dihydroxyvitamin D3 on voltage-sensitive calcium channels in osteoblast differentiation and morphology
2011, Vitamin D: Two-Volume SetFunctional roles of a C-terminal signaling complex of Ca<inf>v</inf>1 channels and A-kinase anchoring protein 15 in brain neurons
2011, Journal of Biological ChemistryCitation Excerpt :Calcium influx via postsynaptic CaV1 channels supports sustained phosphorylation of cAMP response element-binding protein (CREB)3 and CREB-dependent gene expression in hippocampal neurons (6–13). Functional CaV1 channels are multimeric complexes composed of pore-forming α1 and associated α2δ, β, and in some cases, γ subunits (14–19). These channels have an extended C terminus containing many protein interaction sites for regulation (5).