CommentaryRethinking receptor-G protein-effector interactions
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Cited by (76)
Fine-tuning of GPCR signals by intracellular G protein modulators
2013, Progress in Molecular Biology and Translational ScienceCitation Excerpt :A mechanism based on random collisions between G proteins and their receptors and effectors would imply that all compatible signaling partners can interact within the plasma membrane of a cell; however, signaling among the dozens of GPCRs within a typical cell tends to be discrete and many biochemically possible pathways evidently are not utilized.15–18 An alternate view is that G proteins do not shuttle freely between GPCR and effector proteins,19 which in turn suggests that signaling complexes containing receptor, G protein and effector can exist.14 The latter idea is supported by a considerable body of physical and functional evidence,20 and in some cases GPCRs, G proteins, and effectors are found to form stable complexes through which signaling can occur.20,21
Agonist-selective dynamic compartmentalization of human mu opioid receptor as revealed by resolutive FRAP analysis
2010, Journal of Biological ChemistryCitation Excerpt :GPCR are remarkably efficient and rapid at transmitting the signal despite the involvement of interactions with numerous partners. Thus, compartmentalization of the receptors with their partners, G-proteins and effectors, may explain the signal transduction properties (6–8). The dynamics of GPCR in the plasma membrane and its relationship with receptor function are central to the actively developing field of research that is the functional and structural organization of cell membranes (9–11).