CommentariesThe homeodomain-containing proteins: An update on their interacting partners
Section snippets
In vitro and in vivo specificities of the Hox gene products: Role of the cofactors
DNA–protein interactions clearly contribute to the in vivo specificity of each HOX protein 18, 19. The identification of the functional domains of HOX gene products appears to depend on the target DNA sequence but also on the physiological context in which the HOX proteins interact with the DNA [20], thus suggesting that interactions with other proteins, defined as “cofactors,” are required to regulate their function.
In the search for Hox interacting partners, the first candidates to be
Conclusions
Significant progress has been made recently regarding the molecular characterization of the transcriptional complexes involving HOX gene products. The aim of this commentary was to demonstrate tentatively that elucidation of genetic programs regulated by HOX genes can be achieved through identification of HOX interacting partners. Although it is likely that most of the actors still have to be defined, it is clear that further investigations regarding the way the known HOX partners interact with
Acknowledgements
The authors are grateful to Carine van Lint for helpful discussions and to Ulrich Siebenlist for his support. Alain Chariot is a Research Assistant at the University of Liege and is supported by postdoctoral grants from the NATO and the Fulbright Commission. Vincent Bours and Marie-Paule Merville are Research Associates of the National Fund for Scientific Research (“FNRS,” Belgium).
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HOX genes and the NF-κB pathway: A convergence of developmental biology, inflammation and cancer biology
2020, Biochimica et Biophysica Acta - Reviews on CancerCitation Excerpt :However, not much is known about their nuclear partners, other than the well-known TALE group of proteins. The N-terminus of HOXB7 has been shown to interact with the Ankyrin and C-terminal domains of IKB-α [111,112]. It has been suggested that HOXB7 is responsible for the nuclear import of IKB-α.
HOX genes function in Breast Cancer development
2020, Biochimica et Biophysica Acta - Reviews on CancerCitation Excerpt :Indeed, the 3′- 5′ order of the HOX genes within the clusters typically correlates with their temporal and spatial expression along the embryonic anterior-posterior axis, which has been associated with the existence of common regulatory elements [24]. Structurally, HOX genes contain two exons and one intron and their functions rely on an evolutionarily conserved 60 amino-acid homeodomain responsible for DNA binding at specifically recognized sites, resulting in transcriptional inhibition or activation of target genes [25]. This domain is encoded by exon 2 and contains three alpha helices.
MiR-135a functions as a tumor suppressor in epithelial ovarian cancer and regulates HOXA10 expression
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