Elsevier

Brain Research

Volume 972, Issues 1–2, 16 May 2003, Pages 216-221
Brain Research

Short communication
5-HT2A receptor stimulation by DOI, a 5-HT2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens

https://doi.org/10.1016/S0006-8993(03)02516-2Get rights and content

Abstract

(±)-([1-(2,5-Dimethoxy-4-iodophenyl)-aminopropane]-hydrochloride) (DOI) (2.5 mg/kg), a 5-HT2A/2C agonist, significantly potentiated d-amphetamine (AMPH) (1 mg/kg)-induced dopamine (DA) release in rat medial prefrontal cortex (mPFC) and nucleus accumbens (NAC). This effect of DOI was completely prevented by M100907 (1 mg/kg), a selective 5-HT2A antagonist, which by itself had no effect on basal and AMPH-induced DA release in either region. Thus, 5-HT2A receptor agonism potentiates AMPH-induced DA release in the mPFC and NAC.

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Acknowledgements

The present study was supported in part by the William K. Warren Foundation.

References (41)

  • J.-F. Liégeois et al.

    5-HT2A receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner

    Brain Res.

    (2002)
  • M.J. Millan et al.

    Serotonin (5-HT)2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo

    Neuropharmacology

    (1998)
  • E.A. Pehek et al.

    Ritanserin administration potentiates amphetamine-stimulated dopamine release in the rat prefrontal cortex

    Prog. Neuro-Psychopharmacol. Biol. Psychiatry

    (1997)
  • E.A. Pehek et al.

    M100,907, a selective 5-HT2A antagonist, attenuates dopamine release in the rat medial prefrontal cortex

    Brain Res.

    (2001)
  • G. Porras et al.

    5-HT2A and 5-HT2C/2B receptor subtypes respectively modulate dopamine release induced in vivo by amphetamine and morphine in both the rat nucleus accumbens and striatum

    Neuropsychopharmacology

    (2002)
  • C.J. Schmidt et al.

    5-HT2 receptors exert a state-dependent regulation of dopaminergic function: studies with MDL100,907 and the amphetamine analogue, 3,4-methlenedioxymethamphetamine

    Eur. J. Pharmacol.

    (1992)
  • F.X. Vollenweider et al.

    5-HT modulation of dopamine release in basal ganglia in psilocybin-induced psychosis in man—a PET study with [11C]raclopride

    Neuropsychopharmacology

    (1999)
  • B.J. Bowers et al.

    Serotonin 5-HT2 receptor stimulation of dopamine release in the posterior but not anterior nucleus accumbens of the rat

    J. Neurochem.

    (2000)
  • A. Breier et al.

    Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method

    Proc. Nat. Acad. Sci. USA

    (1997)
  • D.B. Carr et al.

    Dopamine terminals in the rat prefrontal cortex synapse on pyramidal cells that project to the nucleus accumbens

    J. Neurosci.

    (1999)
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