Research reportThe phospholipase A2 inhibitor, quinacrine, reduces infarct size in rats after transient middle cerebral artery occlusion
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2021, Drug Discovery TodayCitation Excerpt :No severe drug-related adverse events regarding mortality were observed [101]. Moreover, other PLA2 inhibitors, including quinacrine and arachidonyl trifluoromethyl ketone, were reported to reduce infarct size in rats following transient MCAO administration [102] and exhibited potent neuroprotection activity following spinal cord injury [103]. In general, inhibiting PLA2 exhibited promising neuroprotective ability in stroke treatment.
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2016, Brain ResearchPhospholipase A <inf>2</inf>, reactive oxygen species, and lipid peroxidation in cerebral ischemia
2006, Free Radical Biology and MedicineProtective effects of FBD - An experimental Chinese traditional medicinal formula on memory dysfunction in mice induced by cerebral ischemia-reperfusion
2005, Journal of EthnopharmacologyCitation Excerpt :Taken together, this research may account for the antioxidant effect of FBD, thought to be derived from its herbal constituents and active compounds. In the development of neuronal injury following transient focal ischemia, it has been found the phospholipase A2 (PLA2) plays an important role (Estevez and Phillis, 1997). Overstimulation of this enzyme during cerebral IR results in the accumulation of bioactive metabolites such as arachidonic acid, oxygenated derivatives of arachidonic acid, and platelet-activating factor (PAF), several of these bioactive lipids participate in cell damage and death (Bazan et al., 1995).