Rapid communicationSuppression of feeding-evoked dopamine release in the rat nucleus accumbens by the blockade of P2 purinoceptors
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Acknowledgements
The authors would like to thank Mrs. K. Krause and Mrs. M. Noack for their technical assistance.
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Cited by (18)
Purine-cytokine interactions in methamphetamine-induced behaviors
2023, Brain, Behavior, and ImmunityPurinergic P2X7 receptor antagonist inhibits methamphetamine-induced reward, hyperlocomotion, and cortical IL-7A levels in mice: A role for P2X7/IL-17A crosstalk in methamphetamine behaviors?
2023, Brain, Behavior, and ImmunityCitation Excerpt :Dopamine release in the NAC is increased by ICSS, and ICSS is further enhanced by drugs that enhance extracellular dopamine (e.g., METH) but inhibited by drugs that block dopamine transmission (Negus and Miller, 2014). ATP enhances extracellular dopamine in the rat striatum, and a P2X/Y receptor agonist (2-methylthio ATP) increases striatal dopamine levels and locomotor activity (Krügel et al., 1999, 2001; Kittner et al., 2000, 2001). Amphetamine-evoked hyperactivity, which is also mediated by increased dopamine transmission, is reduced by P2X7 receptor antagonism or genetic deletion (Gubert et al., 2016, 2020; Bhattacharya et al., 2013; Csölle et al., 2013).
Obesity - A neuropsychological disease? Systematic review and neuropsychological model
2014, Progress in NeurobiologyCitation Excerpt :In vivo studies show that endogenous ATP as well as its exogenously applied analogs facilitate dopaminergic functioning (Krugel et al., 1999). The administration of 2-methylthio-ATP (2-MeSATP) into dopaminergic neurons in the VTA and the NA increases extracellular dopamine concentrations in a dose-dependent manner (Krugel et al., 2001b), while the infusion of P2 receptor antagonists as well as long-term food restriction reduce extracellular dopamine levels (Kittner et al., 2000; Pothos, 2001). Overall, ATP has an influence on the decision to eat via modulating accumbal dopamine levels (Ishiwari et al., 2004).
Purinergic signalling: From normal behaviour to pathological brain function
2011, Progress in NeurobiologyCitation Excerpt :The influence of accumbal A2A receptors on reward-driven feeding in a sated state was demonstrated by the facilitatory effect of A2A receptor inhibition on opioid-driven consumption of a high-fat diet (Pritchett et al., 2010). In the striatum, extracellular ATP and adenosine regulate feeding-associated mesolimbic neuronal activity in an antagonistic manner in a strong correlation to the extracellular dopamine concentration induced by the non-selective antagonists PPADS and 8-(p-sulfophenyl)theophylline for P2 and A1/A2 receptors, respectively (Kittner et al., 2000a, 2004b). Moreover, ecto-nucleotidases regulate the levels of adenosine involved in feeding behaviour in the rat brain (Belcher et al., 2006).
Modulation by D1 and D2 dopamine receptors of ATP-induced release of intracellular Ca<sup>2+</sup> in cultured rat striatal neurons
2008, Neurochemistry International