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Suppression of feeding-evoked dopamine release in the rat nucleus accumbens by the blockade of P2 purinoceptors

https://doi.org/10.1016/S0014-2999(00)00731-7Get rights and content

Abstract

In order to investigate whether endogenous adenosine 5′-triphosphate (ATP) is involved in the regulation of feeding, the influence of the P2 receptor antagonist pyridoxalphospate-6-azophenyl-2′,4′-disulphonic acid (PPADS) infused into the rat nucleus accumbens on 18-h food-deprived feeding was tested. PPADS suppressed the feeding-induced dopamine release and reduced the amount of food consumed as well as the time of feeding. These results indicate that activation of P2 purinoceptors by endogenous ATP facilitates feeding behaviour and contributes to the feeding-associated dopamine release.

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Acknowledgements

The authors would like to thank Mrs. K. Krause and Mrs. M. Noack for their technical assistance.

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