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Effect of 7-nitroindazole on drug-priming reinstatement of d-methamphetamine-induced conditioned place preference

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Abstract

The study investigated the role of nitric oxide (NO) in the relapse to drug-seeking behavior induced by d-methamphetamine. After the induction of d-methamphetamine (1 mg/kg) conditioned place preference, the rewarding effect became extinct 6 weeks later. The extinguished place preference was reinstated by d-methamphetamine (0.125 mg/kg) injection, an effect which was attenuated by 7-nitroindazole (12.5 and 25 mg/kg) pretreatment. The results demonstrate that NO is involved in relapse primed by d-methamphetamine injection.

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    Many studies have documented that NO synthesis is involved in the expression of behavioral effects of METH and also, can affect mesolimbic dopamine system. It has been demonstrated that pretreatment with 7-nitroindazole, a NO inhibitor, attenuated the reinstatement of METH (Li et al., 2002a). Furthermore, the administration of 7-nitroindazole before METH treatment could significantly attenuate the acquisition and expression of METH-induced CPP (Li et al., 2002b).

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    Recent studies have applied CPP to test the reinstatement of drug, mostly for cocaine and morphine (Aguilar et al., 2009). Only a few studies reported on the reinstatements of drug CPP using AMP and its derivatives including d, l-AMP (Cruz et al., 2008, 2010), methamphetamine (Li et al., 2002; DeMarco et al., 2009; Qi et al., 2009; Do Couto et al., 2011; Yu et al., 2011; Abulseoud et al., 2012; Berry et al., 2012; Subiah et al., 2012) and 3,4-methylenedioxymethylamphetamine (MDMA) (Daza-Losada et al., 2011; Vidal-Infer et al., 2012). To our knowledge, the present work is the first in reporting drug-primed CPP reinstatement using d-AMP.

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