Characterization of histamine receptors in the ureter of the dog

doi:10.1016/S0014-2999(96)00765-0

European Journal of Pharmacology

Volume 318, Issues 2–3, 30 December 1996, Pages 395-402

https://doi.org/10.1016/S0014-2999(96)00765-0 Get rights and content

Abstract

We investigated the effects of histamine on the motility of isolated segments from canine ureters and characterized pharmacologically the histamine receptors involved. We also evaluated the effects of various autacoids (5-HT, carbachol, noradrenaline, thromboxane, prostaglandin F_2α) on the motility of canine ureters. Histamine as well as the H₁ receptor agonist 2-(2-pyridyl)ethylamine elicited a concentration-dependent contraction. This contractile response was antagonized by dimethindene, causing a rightward shift (pA₂ 8.30) and a reduction of the slope and the maximal effect (pD′₂ 6.01) of the concentration-response curve. The histamine H₂ receptor antagonist cimetidine in a concentration of 10⁻⁵ mol/l was ineffective concerning the concentration-response curve for histamine. After precontraction of the ureter segments (5-HT, carbachol, prostaglandin F_2α), a concentration-dependent relaxant effect was evaluated in the presence of histamine or the histamine H₂ receptor agonist impromidine. The histamine H₂ receptor antagonist cimetidine attenuated the relaxant response, causing a rightward shift of the concentration-response curve. All autacoids except thromboxane were capable of increasing contractility in canine ureters. Comparing the absolute contractile force in the presence of prostaglandin F_2α. 5-HT, carbachol, noradrenaline and potassium, we found that histamine exhibits the most marked effect on this parameter in the canine ureter. It is concluded that there are two types of histamine receptors modulating contractile activity in the canine ureter: histamine H₁ receptors, which mediate contraction, and histamine H₂ receptors, which mediate relaxation (in the precontracted tissue).

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These agents are mostly used in allergic reactions in oral, nasal, or topical forms.24 Although in vivo studies were held on this subject,9–12,20–22 our study constitutes the first clinical study suggesting the role of antihistaminic agents in renal colic. It was considered that dimenhydrinate, which is also used as an antiemetic, can be effective in patients who have renal colic that is accompanied by nausea and vomiting.
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Our previous findings suggest that contractile responses in ureters isolated from different ages vary with agonists, with ureteral contractions to α1-adrenoceptor stimulation being greater in older animals, whilst contractions to 5-HT were smaller in younger animals (Lim, Chess-Williams, & Sellers, 2018a). However, the influence of age on responses mediated by carbachol and histamine, which have both been suggested to mediate ureteral contraction (Dodel, Hafner, & Borchard, 1996; Yalcin et al., 2013), have not been studied. As it is difficult to obtain viable human ureteral tissues, porcine tissue can be used as a model reflecting mechanisms controlling ureteral contractility in humans.
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Isolated ureteral strips from young (6-month old) and older (3-year old) pigs were mounted in organ baths and subjected to phenylephrine, 5-HT, carbachol and histamine. Ureteral strips developed bursts of contractile activity which was measured as area under the curve (AUC) and frequency. Phenylephrine and 5-HT-induced responses of proximal and distal ureters were obtained, in the presence and absence of indomethacin (10 μM) and L-NNA (100 μM), and the influence of an intact mucosa was examined.
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View full text

Characterization of histamine receptors in the ureter of the dog

Abstract

Pharmacol. Res. Commun.

Gastroenterology

Eur. J. Pharmacol.

Neurosci. Lett.

Urology X

Life Sci

Trends Neurosci.

Biochem. Biophys. Res. Commun.

Eur. J. Pharmacol.

Eur. J. Pharmacol.

Eur. J. Pharmacol.

Eur. J. Pharmacol.

Gen. Pharm.

Eur. J. Pharmacol.

Effects of histamine on the human penis muscle in vitro

Eur. J. Pharmacol.

New evidence for prostaglandin induced motility of the ureter

Scand. J. Urol. Nephrol.

Pharmacology of lower urinary tract smooth muscles and penile crectile tissue

Pharmacol. Rev.

Highly potent and selective ligands for histamine H3 receptors

Nature

H3 receptor and control of histamine release

The Logit-Transformation

Histamine receptors in the lung

An update on histamine H3 receptors and gastrointestinal functions

Dig. Dis. Sci.

Electrophysiological characterization of histamine receptor subtypes in mammalian heart preparations, Naunyn-Schmied

Arch. Pharmacol.

Synthese positiv inotroper Substanzen: Imidazolylpropylguanidine mit Pyridin-Partialstruktur

Arch. Pharm. (Weinheim)

Characterization of the histamine receptors in the guinea-pig lung: evidence for relaxant histamine H3 receptors in the trachea

Br. J. Pharmacol.

Antagonists of H1 receptors of histamine, recent developments

Studies on the isolated dog ureter

The pharmacological action of histamine, levanterol and antihistaminics

Arch. Int. Pharmacodyn. Ther.

The action of the prostaglandins on isolated human ureteric smooth muscle

Br. J. Urol.

Pharmacological analysis of 5-Hydroxytryptamine effects on electrically stimulated human isolated urinary bladder

Br. J. Pharmacol.

Histamine-induced venodilatation in human beings involves both H1 and H2 receptor subtypes

J. Allergy Clin. Immunol.

Impromidine (SK&F 92676) is a very potent and significant agonist for histamine H2 receptors

Nature

Histamine in the heart

Eur. J. Clin. Invest.

Histamine H3-signaling in the heart: possible involvement of Gi/G0 proteins and N-type Ca2+ channels

J. Pharmacol Exp. Ther.

Histamine H2 receptors and lung function

Characterization of the rabbit detrusor response to histamine through pharmacologic antagonism

Pharmacology

Histamine receptors on submucuous neurons in guinea-pig colon

Am. J. Physiol.

Influence of serotonin on the human ureter: an in vitro pharmacological study

Urol. Int.

New aspects of the role of histamine in cardiovascular function: identification, characterization, and potential pathophysiological importance of H3 receptors

Can. J. Physiol. Pharmacol.

Highly potent and selective ligands for histamine H₃ receptors

H₃ receptor and control of histamine release

An update on histamine H₃ receptors and gastrointestinal functions

Characterization of the histamine receptors in the guinea-pig lung: evidence for relaxant histamine H₃ receptors in the trachea

Antagonists of H₁ receptors of histamine, recent developments

Histamine-induced venodilatation in human beings involves both H₁ and H₂ receptor subtypes

Impromidine (SK&F 92676) is a very potent and significant agonist for histamine H₂ receptors

Histamine H₃-signaling in the heart: possible involvement of G_i/G₀ proteins and N-type Ca²⁺ channels

Histamine H₂ receptors and lung function

New aspects of the role of histamine in cardiovascular function: identification, characterization, and potential pathophysiological importance of H₃ receptors