Circulating prostaglandin E2 concentrations and patent ductus arteriosus in fetal and neonatal lambs1
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Cited by (94)
Patent Ductus Arteriosus in the Preterm Infant
2023, Avery's Diseases of the NewbornDuctus arteriosus and fetal echocardiography: Implications for practice
2018, Seminars in Fetal and Neonatal MedicineCitation Excerpt :In the few hours after birth the DA might demonstrate bidirectional shunting, but as the pulmonary vascular resistance decreases, the shunt becomes solely left-to-right. This change leads to higher PaO2 levels in the DA, which, in addition to the decrease in prostaglandin levels, results in DA constriction by means of contraction of the smooth muscle of the media [8,11]. Functional closure of the DA occurs within the first 72 h of life in the vast majority of term babies [12].
Comparative physiology of the ductus arteriosus among vertebrates
2018, Seminars in PerinatologyCitation Excerpt :PGE2 is predicted to have a smaller role in maintaining avian ductus patency compared with the mammalian ductus. Circulating plasma levels of PGE2 in mammalian fetus have been found to be around 10–9 M.40 The circulating levels of PGE2 in the developing chicken embryo are unknown, but there are measurable levels of PGE2 and COX activity in the chorioallantoic membrane (CAM) during development.41 This suggests that if PGE2 is involved in maintaining patency then it could be coming from the CAM.
Mechanisms Regulating Closure of the Ductus Arteriosus
2017, Fetal and Neonatal Physiology, 2-Volume SetPatent ductus arteriosus in the preterm infant
2011, Avery's Diseases of the NewbornMechanisms Regulating Closure of the Ductus Arteriosus
2011, Fetal and Neonatal Physiology E-Book, Fourth Edition
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Supported by a grant from the United States Public Health Service, HL 06285.
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Dr. Clyman is the recipient of a Young Investigator's Award from the National Heart, Lung, and Blood Institute, HL 21409.