Original articlesWhy do asthmatic subjects respond so strongly to inhaled adenosine?
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Evaluation of SSR161421, a novel orally active adenosine A<inf>3</inf> receptor antagonist on pharmacology models
2013, European Journal of PharmacologySpasmolytic effect of novel antagonists of the adenosine A<inf>2</inf> receptor in isolated guinea pig tracheal smooth muscle
2013, Biomedicine and Aging PathologyCitation Excerpt :Adenosine, an ubiquitous signalling purine nucleoside, plays a pivotal role in asthma and various allergic conditions [1]. Adenosine receptors produce bronchoconstriction through bronchial smooth muscles cells contraction via G-protein signalling [2–6]. At present, four major subclasses of adenosine receptors A1, A2A, A2B, and A3 have been identified and are known to couple with adenyl cyclase [7].
A facile and rapid one-step synthesis of 8-substituted xanthine derivatives via tandem ring closure at room temperature
2012, TetrahedronCitation Excerpt :Conventionally, substitution at the 8-position of the xanthine ring is accessible by the reaction of a 5,6-diamino-1,3-dialkyluracil derivative 1 with an appropriately substituted aldehyde in two-step procedure (Scheme 1). Herein, the first step involves the formation of 6-amino-5-imino-1,3-dialkyluracil intermediate 2 in presence of acetic acid in MeOH6a–g or EtOH7a–d under refluxing condition or, at room temperature for several hours. The second step proceeds via intramolecular ring closure reaction of 2, to the imidazole ring, which ultimately results in the formation of xanthine derivatives 3.
Molecular modeling study on potent and selective adenosine A<inf>3</inf> receptor agonists
2010, Bioorganic and Medicinal Chemistry