Original articlesEffects of chronic L-NAME treatment on rat focal cerebral ischemia and cerebral vasoreactivity
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Role of α-adrenoceptors and prostacyclin in the enhanced adrenergic reactivity of goat cerebral arteries after ischemia-reperfusion
2010, Brain ResearchCitation Excerpt :Observations made by others indicate that hypoxia is a stimulus that increases gene expression of α1-adrenoceptors in arterial blood vessels (Eckhart et al., 1996). Our results, however, contrast with those performed in anesthetized newborn pigs where 20 min of global cerebral ischemia induced by intracranial hypertension, followed by 2–3 h or 24 h of reperfusion did not affect the reactivity of pial arteries to noradrenaline (Leffler et al., 1989b), and also with those performed in rats where long-term inhibition of NO synthesis with l-NAME reduced the in vitro cerebral vasoconstrictor response to noradrenaline and the vasodilator response to acetylcholine, after occlusion of the left middle cerebral artery for 8–9 weeks, without reperfusion (Sercombe et al., 2001). The discrepancies between these two studies (Leffler et al., 1989b; Sercombe et al., 2001) and ours may be related to differences in the duration of ischemia, the presence or not of reperfusion, the procedure to examine vascular response, and/or perhaps in species used.
Nitric oxide synthase inhibitors in experimental ischemic stroke and their effects on infarct size and cerebral blood flow: A systematic review
2005, Free Radical Biology and Medicine